PMID: 6979605Jul 1, 1982Paper

Anti-Ia antibody in the sera of normal subjects after in vivo antigenic stimulation

The Journal of Experimental Medicine
K OkudairaR C Williams

Abstract

We showed that sera from normal subjects after antigenic challenge with intradermal PPD or Candida antigens or with subcutaneous tetanus vaccine contain a factor that blocks the binding of mouse monoclonal anti-Ia antibody to Ia-positive T cells or to B35 M cells, an Ia-positive human B cell line. The blocking activity appears 48 to 72 h after antigenic challenge and is gone by day 7. The appearance of the anti-Ia blocking activity coincided with a drop in the percentage of Ia-positive T cells and non-T cells in the peripheral blood of these subjects and also with a decrease in the density of surface Ia on the non-T cell population. The blocking was not genetically restricted; that is, serum from a given subject blocked anti-Ia binding to Ia-positive T cells of subjects with different DR haplotypes. The blocking activity was contained in the IgM fraction of the sera. The blocking activity of the sera was eliminated after absorption of the sera with Ia-positive but not with Ia-negative human cell lines. It would appear, therefore, that the blocking of monoclonal anti-Ia binding is caused by an IgM anti-Ia antibody that appears in normals after in vivo antigenic challenge.

References

Jan 1, 1976·Scandinavian Journal of Immunology·R J WinchesterT Hoffman
Mar 1, 1978·The Journal of Clinical Investigation·E G Engleman, H O McDevitt
Dec 14, 1978·Nature·K WimanP A Peterson
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Citations

Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R Palacios
Oct 1, 1983·The Journal of Experimental Medicine·J L PlattA F Michael
Jan 1, 1985·Clinical Immunology and Immunopathology·S RomagnaniR Tosi
Apr 1, 1989·Cellular Immunology·L VaickusR N Bacon
Apr 1, 1983·Arthritis and Rheumatism·R P SearlesJ S Goodwin
Feb 1, 1986·Tissue Antigens·R Cerný-ProvaznikP Iványi
Mar 1, 1992·European Journal of Immunology·A BernemanS Avrameas
May 1, 1990·Clinical Immunology and Immunopathology·L L MarnellW L Sibbitt

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