PMID: 15383611Sep 24, 2004Paper

Anti-idiotype x anti-CD44 bispecific antibodies inhibit invasion of lymphoid organs by B cell lymphoma

The Journal of Immunology : Official Journal of the American Association of Immunologists
Esther AvinNurit Hollander

Abstract

The demonstration that Abs to adhesion molecules can block tumor metastasis suggested their use for therapy. However, such Abs affect nonmalignant cells as well. To circumvent this adverse effect, we proposed the use of bispecific Abs that bind simultaneously to an adhesion receptor and to a tumor-specific Ag. Such bifunctional Abs bind more avidly to tumor cells that coexpress both target Ags than to normal cells. The Id of the surface Ig of malignant B lymphocytes is a tumor-specific Ag. Therefore, we produced bispecific Abs with specificity to the adhesion molecule, CD44, and to an idiotypic determinant of the murine B cell lymphoma, 38C-13. These anti-Id x anti-CD44 bispecific Abs blocked 38C-13 cell adhesion to hyaluronic acid, while not affecting adhesion of Id-negative cells. In vivo studies demonstrated that the bispecific Abs inhibited lymphoma cell dissemination to the lymph nodes, bone marrow, and spleen, and prolonged survival of tumor-bearing mice. Migration of 38C-13 cells to the lymphoid organs was inhibited by the bispecific Abs. Thus, the bispecific Ab-mediated reduction in metastasis resulted, at least in part, from reduced homing to these organs. In contrast to anti-CD44 monospecific Abs, the anti-Id x anti-C...Continue Reading

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Citations

Sep 22, 2009·Journal of Cellular and Molecular Medicine·Mohini RajasagiRachid Marhaba
Feb 8, 2014·Nature Reviews. Cancer·Martin E Hemler
Oct 16, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vibuthi SinghMargot Zöller
Feb 23, 2020·British Journal of Pharmacology·Chongwu WangRuxiang Xu
Mar 1, 2009·Immunotherapy·Nurit Hollander
Jun 18, 2014·Immunology and Cell Biology·Amelie Pajip MegaptcheMargot Zöller
Oct 9, 2007·Experimental Hematology·Margot ZöllerThomas Luft

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