Anti-idiotypes to factor VIII antibodies and their possible role in the pathogenesis and treatment of factor VIII inhibitors

British Journal of Haematology
E H MoffatI R Peake

Abstract

Studies on the production and characterization of anti-idiotype antibodies (AId) to monoclonal factor VIII antibodies (McFVIIIAb) are reported. Two AIds were produced and one of these exhibited cross-reactivity with two other McFVIIIAb but showed no reactivity with haemophilic and non-haemophilic FVIIIAb. This AId was also active against McFVIIIAb which bound immunologically active forms of factor VIII but it did not neutralize McFVIIIAb directed against procoagulant factor VIII. The in vitro effect of therapeutic pooled human IgG concentrates upon haemophilic and non-haemophilic FVIIIAb was also assessed. Approximately 25% of non-haemophilic FVIIIAb were inhibited following incubation with human IgG whereas the latter had no effect upon haemophilic FVIIIAb activity. Studies on haemophilic sibling pairs of FVIIIAb and non-FVIIIAb producing individuals indicated FVIIIAb neutralizing activity in the non-FVIIIAb producing sibling's IgG fraction which may be of anti-idiotypic origin. These findings lend further support to suggestions that anti-idiotypes have a regulatory role in FVIIIAb production and are of potential therapeutic value.

References

Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C A FulcherT S Zimmerman
Oct 3, 1985·The New England Journal of Medicine·S E AntonarakisD N Fass
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·Y SultanM D Kazatchkine
Nov 1, 1969·Archives of Biochemistry and Biophysics·M Steinbuch, R Audran
Sep 1, 1969·British Journal of Haematology·P BeckA L Bloom

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Citations

Jun 1, 1992·Biologicals : Journal of the International Association of Biological Standardization·T Burnouf
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B C Lubahn, H M Reisner
Jan 1, 1991·Annals of the New York Academy of Sciences·C K Kasper
May 1, 1996·Annals of Hematology·J BatlleM F López-Fernández
May 20, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·D Green
Nov 1, 1989·Clinical Immunology and Immunopathology·U E NydeggerM D Kazatchkine
Oct 1, 1995·Haemophilia : the Official Journal of the World Federation of Hemophilia·S AronisA Mitsika
Nov 1, 1989·American Journal of Hematology·C TiarksR E Humphreys

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