PMID: 7028910Nov 1, 1981Paper

Anti-idiotypes to monoclonal anti-H-2 antibodies. II. Expression of anti-H-2Kk idiotypes on antibodies induced by anti-idiotype or H-2Kk antigen

The Journal of Experimental Medicine
J A BluestoneD H Sachs

Abstract

Anti-idiotypic antibodies were prepared against two monoclonal anti-H-2Kk antibodies, 11-4.1 and 3-83P. These reagents were used to examine idiotype (Id) expression on anti-H-2Kk antibodies induced by the in vivo administration of the anti-idiotypic antibodies and/or H-2Kk antigen. Treatment of BALB/c mice with anti-Id induced both antigen-binding and nonantigen-binding Id-positive molecules in the absence of antigen. The level of production of anti-Id-induced Id (Id') has been shown to be linked to VH genes using allotype congenic mice and backcross analyses. The idiotypes expressed on the Id' induced in anti-Id-treated mice were closely related or identical to those of the original monoclonal anti-H-2Kk antibody. However, the idiotopes were present on immunoglobulins of different subclasses and in some cases were not all expressed on the same molecules, as reflected by differences in their antigen specificities and isoelectric focusing patterns. In vivo administration of anti-Id had a marked influence on the subsequent humoral response to immunization with H-2 antigen.

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Citations

Aug 1, 1983·Journal of Virological Methods·R C Kennedy, G R Dreesman
Mar 19, 2002·Xenotransplantation·Isabel M McMorrowChristian LeGuern
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J A BluestoneD H Sachs
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G T NepomK E Hellström
Aug 1, 1985·The Journal of Experimental Medicine·R RabinowitzD H Sachs
Apr 1, 1986·Immunological Reviews·M SlaouiJ Urbain
Apr 1, 1986·Immunological Reviews·F G UytdeHaagA D Osterhaus
Apr 1, 1986·Immunological Reviews·J A BluestoneD H Sachs
Jan 1, 1983·Annals of the New York Academy of Sciences·D H SachsR Rabinowitz
Aug 1, 1988·International Reviews of Immunology·D H Sachs
Mar 24, 2005·Infection and Immunity·Michelle A ParentStephen T Smiley
Mar 29, 2005·World Journal of Gastroenterology : WJG·Fan-Ping MengDai-Ming Fan
Apr 1, 1982·European Journal of Immunology·R Grützmann, G J Hämmerling
Apr 15, 1982·International Journal of Cancer. Journal International Du Cancer·H BinzH Wigzell

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