PMID: 8938275Dec 1, 1995Paper

Anti-idiotypic monoclonal antibody cancer vaccines

Seminars in Cancer Biology
P B Chapman

Abstract

Anti-idiotypic monoclonal antibodies (MAb) can mimic both protein and non-protein antigenic epitopes. In animal models, and now in patients, it is possible to induce immune responses against tumor antigens using anti-idiotypic MAb vaccines. While it is not clear how the efficacy of anti-idiotypic MAb vaccines compares with the efficacy of vaccines constructed from antigen, there are two situations where anti-idiotypic vaccines have potential advantages: (1) when the antigen is not readily available in sufficient quantities or purity, and (2) when the antigen is a non-protein. Clinical trials are underway using anti-idiotypic MAb vaccines in both of these situations.

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Citations

May 29, 2002·Hybridoma and Hybridomics·Behjatolah Monzavi-KarbassiThomas Kieber-Emmons
Jul 15, 1999·Nature Biotechnology·T Kieber-EmmonsZ Steplewski
Mar 29, 2005·World Journal of Gastroenterology : WJG·Fan-Ping MengDai-Ming Fan

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