PMID: 9531329Apr 8, 1998Paper

Anti-idiotypic T-cell activation in multiple myeloma induced by M-component fragments presented by dendritic cells

British Journal of Haematology
S DabadghaoQ Yi

Abstract

The monoclonal immunoglobulin (Ig) (M-component) secreted by the tumour plasma cells in multiple myeloma (MM) has specific antigenic determinants (idiotypes; id) that can serve as tumour-specific antigens. The intact Ig molecule is a weak antigen, and small fragments of id protein might be more immunogenic for the induction of id-specific immunity. Dendritic cells (DC) have attracted attention as the most efficient antigen-presenting cells and promising adjuvants for immunotherapy in tumours. In this study the in vitro T-cell response against F(ab')2 and Fab fragments, heavy and light chains of the M-component was examined in five patients with MM clinical stage I. All fragments were able to stimulate T cells but F(ab')2 or Fab fragments and heavy chains induced a stronger response than light chains. DC induced a significantly stronger id-specific immune response than monocytes. Moreover, with DC as antigen-presenting cells, a predominant interferon (IFN)-gamma (type-1 T-cell) response was seen in all patients. Both IFN-gamma and interleukin (IL)-4 (type-1 and type-2 T-cell) responses were noted when monocytes were used. Our study suggests that DC pulsed with idiotypic fragments such as F(ab')2 fragment and heavy chain can be u...Continue Reading

References

Aug 1, 1991·Immunology Today·S Romagnani
Dec 30, 1991·Annals of the New York Academy of Sciences·G HolmH Mellstedt
Jan 1, 1991·Annual Review of Immunology·R M Steinman
May 1, 1991·British Journal of Haematology·S BergenbrantA K Lefvert
Jan 1, 1985·Methods in Enzymology·P D GorevicB Frangione
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·R G LynchH N Eisen
Aug 1, 1994·Scandinavian Journal of Immunology·S BergenbrantA K Lefvert
Jan 1, 1993·International Reviews of Immunology·B Bogen, S Weiss
Jan 1, 1996·The Journal of Experimental Medicine·J W Young, K Inaba
Mar 1, 1996·Immunology Today·T R Mosmann, S Sad
Mar 1, 1996·Stem Cells·R Thomas, P E Lipsky

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Citations

Aug 5, 2004·Current Oncology Reports·Renier J Brentjens
Apr 26, 2002·British Journal of Haematology·Qing YiNikhil Munshi
Dec 17, 2009·The Cancer Journal·Qing Yi
Aug 5, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jinsheng WengLarry W Kwak
Jul 20, 2010·Immunotherapy·David S RitchiePaul Neeson
Sep 1, 2001·Clinical and Experimental Immunology·M A FrassanitoF Dammacco
Jun 1, 2012·Clinical & Developmental Immunology·Ivetta DanyleskoArnon Nagler
Oct 21, 2003·Leukemia & Lymphoma·Daniel M Y SzeaDouglas E Joshua
Feb 13, 2004·Leukemia & Lymphoma·Qing Yi
Sep 16, 2008·Best Practice & Research. Clinical Haematology·Jacalyn Rosenblatt, David Avigan
Jul 27, 2005·British Journal of Haematology·S J Harrison, G Cook
Feb 6, 2002·Pathology·D N Hart, UNKNOWN Board of Education of The Royal College of Pathologists of Australasia
Dec 24, 2005·Pathology·Kristen J RadfordDerek N J Hart
Mar 28, 2008·Biochemical and Biophysical Research Communications·Monica RinaldiVito Michele Fazio
May 11, 2010·Expert Review of Vaccines·David Avigan, Dimitrios Tzachanis
Feb 11, 2020·Human Vaccines & Immunotherapeutics·Ningbo Zheng, Yong Lu
Mar 5, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jooeun BaeHans G Klingemann
Oct 20, 1999·Blood Reviews·G Cook, J D Campbell

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