Anti-IgE for chronic asthma in adults and children

The Cochrane Database of Systematic Reviews
S WalkerE H Walters

Abstract

Omalizumab is a recombinant humanised monoclonal antibody directed against immunoglobulin E (anti-IgE) to inhibit the immune system's response to allergen exposure. Omalizumab is directed against the binding site of IgE for its high affinity Fc receptor. It prevents free serum IgE from attaching to mast cells and other effector cells and prevents IgE mediated inflammatory changes. To determine the efficacy of anti-IgE compared with placebo in patients with allergic asthma We searched the Cochrane Airways Group Asthma trials register for potentially relevant studies (February 2006). Randomised controlled trials examining anti-IgE administered in any manner for any duration. Trials with co-interventions were included as long as they were the same in each arm. Two reviewers independently assessed study quality and extracted and entered data. Three modes of administration were identified from the published literature (inhaled, intravenous and subcutaneous injection). Subgroup analysis was performed by asthma severity. Data were extracted from published and unpublished sources. Fourteen trials (15 group comparisons) were included in the review, contributing a total of 3143 mild to severe allergic asthmatic participants with high lev...Continue Reading

Citations

Sep 8, 2011·BMC Medicine·Neil C ThomsonMark Spears
Jan 1, 2010·Journal of Asthma and Allergy·Jaymin B Morjaria, Riccardo Polosa
Jun 28, 2011·Journal of Asthma and Allergy·Joshua Agbetile, Ruth Green
Jun 30, 2012·Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine·Neil C Thomson, Rekha Chaudhuri
Sep 10, 2009·Clinical and Experimental Immunology·D Desai, C Brightling
Oct 2, 2007·The Journal of Allergy and Clinical Immunology·Ann C WuAnne L Fuhlbrigge
Mar 6, 2007·Seminars in Fetal & Neonatal Medicine·Godfrey J A Walker, Damian G Walker
Feb 11, 2012·Therapeutic Advances in Respiratory Disease·Francesco MenzellaLuigi Zucchi
Jan 15, 2014·The Cochrane Database of Systematic Reviews·Rebecca NormansellParameswaran Nair
May 26, 2011·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Francesco MenzellaLuigi Zucchi
Oct 23, 2008·Current Allergy and Asthma Reports·Noel Rodríguez-PérezJay M Portnoy
Dec 7, 2007·Allergy·L B BacharierUNKNOWN European Pediatric Asthma Group
Dec 17, 2014·The European Respiratory Journal·Claus VogelmeierKlaus F Rabe
Aug 3, 2011·Nature Reviews. Rheumatology·Gillian M BellJohn D Isaacs
Jan 31, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B S Bochner
Feb 4, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R H Dougherty, J V Fahy
Jul 27, 2011·Current Allergy and Asthma Reports·Ritesh Agarwal
Nov 2, 2013·Clinical Reviews in Allergy & Immunology·T E AlbertsonS Louie
Apr 12, 2013·Paediatric Drugs·Alexandra Adams, Sejal Saglani
Oct 30, 2003·The Cochrane Database of Systematic Reviews·T DeanE H Walters
Sep 11, 2008·Allergy·C Rolinck-WerninghausUNKNOWN Omalizumab Rhinitis Study Group
Feb 8, 2020·Analytical and Bioanalytical Chemistry·Sha GuoLan Wang
Jan 19, 2011·Current Allergy and Asthma Reports·Matthias Volkmar Kopp
Nov 18, 2008·Respiratory Medicine·Riccardo Polosa, Jaymin Morjaria
Jan 13, 2009·Pediatric Clinics of North America·Paul D Robinson, Peter Van Asperen
Apr 14, 2009·Respiratory Medicine·Stephen HolgatePablo Jimenez
Nov 10, 2009·The Journal of Allergy and Clinical Immunology·Tmirah HaselkornJames E Fish

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

© 2022 Meta ULC. All rights reserved