PMID: 6978090Nov 1, 1981Paper

Anti-IgG antibodies and antinuclear antibodies in allergic patients

Allergy
E M EgeskjoldH E Kallerup

Abstract

With an indirect immunofluorescence technique 77% of 96 patients with type I allergy and 40% of 20 patients with intrinsic bronchial asthma showed positive reactions for IgG anti-IgG antibodies in serum. They were present partly in an aggregated state not directly detectable before treatment with dithiothreitol. The aggregates could be removed by precipitation with polyethylene glycol. The IgG anti-IgG in hyposensitized patients were directed against both F(ab')2 and Fc fragments of rabbit IgG. Thirty of the type I allergic patients were examined once during hyposensitization as well. Before treatment 87% had IgG anti-IgG (titres 9-72). After greater than or equal to 13 months of treatment 100% were positive (titres 36-288). Eight patients were also examined after hyposensitization had been discontinued for at least 12 months. The titres of IgG anti-IgG had then reverted to the levels obtained before hyposensitization. Of 116 controls matched for sex and age, 7% had IgG anti-IgG antibodies. It is suggested that the production of IgG anti-IgG may be stimulated by the presence of immune complexes and that purity, amount and/or combination of allergens administered during hyposensitization may influence the production of anti-IgG ...Continue Reading

References

May 1, 1979·The Journal of Allergy and Clinical Immunology·W H YangN J Gilmore
Mar 1, 1977·Clinical Allergy·P O CanoJ P Sladowski
Dec 10, 1969·Annals of the New York Academy of Sciences·I BroderD Bell
Nov 1, 1974·Arthritis and Rheumatism·G G Hunder, G J Gleich
Sep 1, 1971·Arthritis and Rheumatism·R J WinchesterH G Kunkel
Aug 1, 1971·Annals of Internal Medicine·R S PanushP H Schur

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