Anti-implantation activity of H2 receptor blockers and meloxicam, a COX-inhibitor, in albino Wistar rats

The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception
S S Agrawal, M Alvin Jose

Abstract

To evaluate the anti-implantation activity of H(2) receptor blockers ranitidine and famotidine, and Cox-inhibitor meloxicam, alone and in combination, considering the role of histamine and prostaglandins in implantation. The drugs were administered orally to female albino Wistar rats at different dose levels for 1 to 7 days, immediately after confirming copulation by observing sperm in the vaginal smear. A laparotomy was done on the 10th day of pregnancy, the implants and corpora lutea were counted, and the pre- and post implantation losses determined. The mast cell stabilising activity was studied using both in vitro and in vivo methods. Ranitidine 70 mg/kg (75.41%; p < 0.01), and famotidine 80 mg/kg (74.30%; p < 0.001) showed significant anti-fertility activity. No increase in activity was seen at higher doses. Meloxicam showed significant activity at doses of 3, 4, and 5 mg/kg. The combination of meloxicam (4 mg/kg) with ranitidine (70 mg) and famotidine (80 mg/kg) showed 100% anti-fertility activity. Our results indirectly confirm the combined involvement of histamine and prostaglandins in the implantation process. The mast cell stabilising property of H(2) blockers appears to be a possible mechanism for their anti-implanta...Continue Reading

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Citations

Jul 21, 2011·Human Reproduction·Stefan CikosJuraj Koppel
Jan 29, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Shyam S AgrawalVarun Singh
Jun 12, 2013·Human Fertility : Journal of the British Fertility Society·Michael CarrollMatthew Helbert
Feb 2, 2011·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·S S Agrawal, M Alvin Jose
Aug 20, 2010·Systems Biology in Reproductive Medicine·Shyam Sundar Agrawal, Manonmani Alvin Jose
Feb 14, 2020·American Journal of Reproductive Immunology : AJRI·Daniel Elieh Ali KomiGerhard Haidl
Nov 7, 2016·Human Reproduction·Kathryn A McInerneyLauren A Wise
Jun 21, 2013·Reproduction in Domestic Animals = Zuchthygiene·T S AguiarL R Martins
Nov 19, 2019·American Journal of Obstetrics and Gynecology·Anne Marie Z JukicAnne Z Steiner

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