PMID: 1208885Dec 1, 1975Paper

Anti-implantation effect of prostaglandins in the rat

Prostaglandins
S K Batta, L Martini

Abstract

PGF2alpha and PGE2 have been instilled in small amounts (5mug) into the uterine horns of pregnant rats at different intervals following mating. Unilateral as well as bilateral injections have been used. Three parameters have been taken into consideration at laparotomy performed on the 13th day of pregnancy: a) the number of implantation sites; b) the number of viable fetuses; and c) the number of corpora lutea present on the ovarian surface. Both PGs proved able to inhibit implantation, to affect the development of embryos and to exert some luteolytic activity when given between D-1 and D-6 of pregnancy.

References

Apr 30, 1971·Annals of the New York Academy of Sciences·P Piper, J Vane
Sep 25, 1974·Prostaglandins·S K SaksenaM C Chang
Nov 10, 1974·Prostaglandins·G Chaudhuri, J Harvey
Feb 16, 1972·Nature: New Biology·P B Marley
Mar 17, 1972·Nature·M C Chang, D M Hunt
Jan 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·K T KirtonA D Forbes
Feb 14, 1970·Nature·P J PiperJ H Wyllie
Apr 30, 1971·Annals of the New York Academy of Sciences·B Pharriss
Apr 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·G D GutknechtB B Pharriss
Aug 1, 1968·The Journal of Obstetrics and Gynaecology of the British Commonwealth·M P Embrey, D L Morrison
Jan 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·B B Pharriss, L J Wyngarden

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