Anti-infectious activity of tryptophan metabolites in the L-tryptophan-L-kynurenine pathway

Biological & Pharmaceutical Bulletin
K NaruiM Sasatsu

Abstract

To study the anti-infectious effect of a vascular allograft, the antimicrobial activity of tryptophan metabolites mediated by indoleamine 2,3-dioxygenase was determined. The growth of methicillin-resistant Staphylococcus aureus (MRSA) over 10 h in extracts from post-transplantation vascular allograft was significantly slower than that of extracts from non-transplantation vascular allograft regardless of the presence of tryptophan (p<0.05). When the antimicrobial activity of the tryptophan metabolites in the L-tryptophan-L-kynurenine pathway was examined, 3-hydroxy-DL-kynurenine and alpha-picolinic acid had strong antibacterial activity against MRSA, S. epidermidis, Escherichia coli, and multidrug-resistant Pseudomonas aeruginosa, although antimicrobial activities of anthranilic acid, 3-hydroxyanthranilic acid, and quinolinic acid against them were low. The results showed that, of the tested tryptophan metabolites, 3-hydroxy-DL-kynurenine and alpha-picolinic acid contributed to the anti-infectious effects of the allograft by inhibiting of the growth of microorganisms.

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Citations

Jun 23, 2011·Journal of Neural Transmission·Trevor W StoneL Gail Darlington
Apr 11, 2012·Extremophiles : Life Under Extreme Conditions·María Victoria OrdóñezRubén Danilo Conde
Feb 22, 2012·Journal of Bioscience and Bioengineering·Takahide SasakiKohsuke Honda
Aug 15, 2012·Immunological Reviews·Tracy L McGahaAndrew L Mellor
Jul 3, 2016·Developmental and Comparative Immunology·Jimena CortésLuis Mercado
Apr 21, 2012·Nature Reviews. Immunology·Lalita Ramakrishnan
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Jul 12, 2018·Interactive Cardiovascular and Thoracic Surgery·Hidemasa NakaminamiNorihisa Noguchi
May 22, 2020·International Journal of Tryptophan Research : IJTR·Monica BorghiLuigina Romani
Feb 1, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Fabio Marcelo CerbánClaudia Cristina Motran
Apr 9, 2021·Pharmacology & Therapeutics·Marta Marszalek-GrabskaWaldemar A Turski
Jul 26, 2017·ACS Medicinal Chemistry Letters·Carolina P KnubelClaudia C Motran
Apr 6, 2019·Journal of Agricultural and Food Chemistry·Richard HammerlThomas Hofmann
Sep 22, 2021·Inorganic Chemistry·Sabina W JarosPiotr Smoleński

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