Anti-inflammatory action of glucagon in rats.

British Journal of Pharmacology
J Garcia LemeM Z Souza

Abstract

1 Subcutaneous administration of glucagon (1 and 0.5 mg/kg) 30 min before the injection of carrageenin or dextran into the rat's paw reduced oedema and the local exudation of Evans blue previously given intravenously. 2 The effect persisted after removal of the adrenal medulla but not after adrenalectomy. 3 When glucagon (1 mg/kg, s.c.) was given daily after a local reaction to Freund's adjuvant injected into the paw had developed, a decrease in the reaction was observed up to 12 days. Blood sugar levels remained within the normal range. 4 Glucagon may exert an anti-inflammatory effect through the release of adrenal corticosteroids and thus help modulate inflammatory reactions.

References

Jan 1, 1975·British Journal of Pharmacology·J G Leme, E E Schapoval
Jul 1, 1973·European Journal of Pharmacology·J G LemeM P Leite
Dec 1, 1974·European Journal of Pharmacology·J Garcia-LemeM Z de Souza
Nov 1, 1972·Psychological Medicine·S R BloomO E Pratt
Sep 1, 1973·The Journal of Clinical Endocrinology and Metabolism·J E GerichP H Forsham
Aug 1, 1970·The American Journal of the Medical Sciences·R H Unger
Jun 23, 1971·Nature: New Biology·V Leclercq-MeyerW J Malaisse
Jan 1, 1967·The Journal of Clinical Investigation·D Porte
Nov 1, 1947·Journal of Clinical Pathology·E J King, R J Garner

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Citations

Jan 1, 1993·Mediators of Inflammation·J Garcia-Leme, S P Farsky
Jan 28, 2015·Human Vaccines & Immunotherapeutics·Benjamin YangChien-Fu Hung

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