PMID: 9535545Apr 16, 1998Paper

Anti-inflammatory action of pale sulfonated shale oil (ICHTHYOL pale) in UVB erythema test

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
J Warnecke, A Wendt

Abstract

In a clinical research institute the anti-inflammatory effect of pale sulfonated shale oil versus hydrocortisone was investigated in a placebo-controlled clinical trial using a double-blind design and random assignment of the treatments to the test fields. 20 male and female volunteers with healthy skin in the test areas participated in this trial. All subjects received different concentrations of pale sulfonated shale oil (2% and 4%), the active ingredient-free vehicle and a reference product containing 0.5% hydrocortisone. Approximately 300 microl of test preparation were applied to the treatment fields. The medication was administered for 23 h. An untreated, irradiated and an untreated, non-irradiated control field were included as well. The test fields were compared intraindividually. Four different UV-doses (1; 1.25; 1.6 and 2 MED) were tested in each volunteer. The test fields were occluded for 6 h. After 7 h, measurement with a colorimeter was carried out. After measurement, the treatment was repeated. The test fields were occluded for a further 16 h and test preparations carefully wiped off. One hour later, post-irradiation color measurements were made by colorimetric detection. Variance analysis was used for statistica...Continue Reading

Citations

Mar 28, 2001·Ryōikibetsu shōkōgun shirīzu·K Nakamura, K Tamaki
Feb 3, 2009·Journal of the American Academy of Dermatology·Kapila V Paghdal, Robert A Schwartz
Jul 14, 2010·International Journal of Dermatology·Alan S Boyd
Mar 20, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·H C KortingUNKNOWN Collaborative Study Group
Jun 14, 2016·Indian Journal of Dermatology·Koushik Lahiri, Arijit Coondoo

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