PMID: 8950305Jan 1, 1996Paper

Anti-inflammatory action of Pluchea sagittalis: involvement of an antioxidant mechanism

Life Sciences
F Pérez-GarcíaT Adzet

Abstract

Pluchea sagittalis, (Lam.) Cabr., a popular medicinal herb grown in South America, was studied for anti-inflammatory and antioxidant activities. The anti-edema action of P. sagittalis aqueous extract was assayed in different models of inflammation: 1) the mouse ear edema test induced by arachidonic acid and croton oil; 2) the rat hind-paw edema test produced by several inflammatory inductors: carrageenan, dextran, zymosan, platelet-activating factor (PAF) and arachidonic acid; 3) a subacute model based on the rat carrageenan air-pouch granuloma test. Blood leukocyte free radical production was measured by flow cytometry with 2',7'-dichlorofluorescin diacetate (DCFH-DA) in vivo, in rats with induced air-pouch granuloma, and in a model in vitro. stimulating leukocytes with hydrogen peroxide. The aqueous extract of P. sagittalis showed a marked anti-inflammatory effect in both ear edema tests, dextran and carrageenan hind-paw edemas and carrageenan air-pouch model. It also had a potent antioxidant activity in blood leukocytes, both in vivo and in vitro. Our results correlate the reduction of free radical production with the anti-inflammatory effect of this plant.

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Citations

Nov 3, 2010·Journal of Ethnobiology and Ethnomedicine·Daniel GarciaEliana Rodrigues
Apr 6, 2007·Biological & Pharmaceutical Bulletin·Upa KukongviriyapanSrisomporn Preeprame
Feb 23, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chung Mu ParkYoung Sun Song
Nov 19, 2013·Chemistry & Biodiversity·Hidayat HussainIftikhar Ali
Sep 12, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·G M NardiR M Ribeiro-do-Valle
May 19, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·F Pérez-GarcíaS Cañigueral
Apr 9, 2001·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·F Pérez-GarcíaS Cañigueral
Mar 12, 2011·Journal of Ethnopharmacology·Sonia Maria FigueredoAdair Roberto Soares Santos
Dec 6, 2000·Immunopharmacology and Immunotoxicology·M L QueirozG M Guilhon
Jan 6, 2015·The Journal of Pharmacy and Pharmacology·Renato Pérez-RosésSalvador Cañigueral
Jun 1, 2006·The Journal of Pharmacy and Pharmacology·Alexandre KanashiroYara M Lucisano-Valim
May 24, 2016·Journal of Agricultural and Food Chemistry·Renato Pérez-RosésSalvador Cañigueral
Aug 16, 2008·Journal of Ethnopharmacology·K T Mani Senthil KumarTuhinadri Sen
Feb 24, 2001·Free Radical Research·F Pérez-GarcíaS Cañigueral
Dec 21, 2011·Asian Pacific Journal of Tropical Medicine·Ouédraogo NoufouGuissou Innocent Pierre
Sep 10, 1999·Phytotherapy Research : PTR·B O LimD K Park

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