Anti-inflammatory actions of herbal formula Gyejibokryeong-hwan regulated by inhibiting chemokine production and STAT1 activation in HaCaT cells

Biological & Pharmaceutical Bulletin
Soo-Jin JeongHyeun-Kyoo Shin

Abstract

Gyejibokryeong-hwan (GJBRH; Keishi-bukuryo-gan in Japan and Guizhi Fuling Wan in China) is a traditional herbal formula comprising five medicinal herbs and is used to treat climacteric syndrome. GJBRH has been shown to exhibit biological activity against diabetes, diabetic nephropathy, atherosclerosis, ischemia, and cancer. However, there is no scientific evidence of its activities against skin inflammation, including atopic dermatitis. We used the HaCaT human keratinocyte cell line to investigate the effects of GJBRH on skin inflammation. No significant cytotoxicity was observed in cells treated with GJBRH up to a concentration of 1000 µg/mL. Exposure to the proinflammatory cytokines tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) significantly increased HaCaT cell production of the following chemokines: macrophage-derived chemokine (MDC)/CCL22; regulated on activation, normal T-cell expressed and secreted (RANTES)/CCL5; and interleukin-8 (IL-8). In contrast, GJBRH significantly reduced the production of MDC, RANTES, and IL-8 compared with control cells simulated with TNF-α and IFN-γ. Consistently, GJBRH suppressed the mRNA expression of MDC, RANTES, and IL-8 in TNF-α and IFN-γ-treated cells. Treatment with GJ...Continue Reading

References

Mar 11, 2003·The Journal of Pharmacy and Pharmacology·Siew Ping YapAi Beoy Lim
Mar 13, 2003·The Journal of Pharmacy and Pharmacology·Takako NakagawaKazuo Nakanishi
Apr 9, 2004·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·H GotoK Terasawa
Aug 28, 2004·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Y ShimadaK Terasawa
Jun 22, 2005·Current Allergy and Asthma Reports·Andor Pivarcsi, Bernhard Homey
Jun 22, 2005·Journal of the American Academy of Dermatology·William Abramovits
Jul 25, 2006·Journal of Dermatological Science·Hidehisa Saeki, Kunihiko Tamaki
Feb 13, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Daniele TorellaCiro Indolfi
Jun 10, 2008·Journal of Neuroimmunology·Stéphane Mélik-Parsadaniantz, William Rostène
Jul 3, 2008·International Immunopharmacology·Jong Soon KangHwan Mook Kim
Sep 2, 2008·Journal of Ethnopharmacology·Zhang Yao, Zhang Shulan
Feb 4, 2010·The American Journal of Chinese Medicine·Kuo-Ching WenHsiu-Mei Chiang
Feb 18, 2010·Biochimie·Imen Najjar, Remi Fagard
Mar 25, 2011·Phytotherapy Research : PTR·Tu HongqinSong Shasha
Jan 10, 2012·Biochemical and Biophysical Research Communications·Dong-Joo KwonJinseu Park
Mar 8, 2012·Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·Ke LiangYing Jia
Sep 6, 2012·International Archives of Allergy and Immunology·Tseveendorj AmarbayasgalanEishin Morita
Aug 13, 2013·Photochemistry and Photobiology·Visa ThongrakardTewin Tencomnao
Nov 13, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hye-Sun LimHyeun-Kyoo Shin
Apr 12, 2014·Nature Reviews. Immunology·Manolis PasparakisFrank O Nestle

❮ Previous
Next ❯

Citations

Jan 24, 2018·BMC Complementary and Alternative Medicine·Mee-Young LeeHyeun-Kyoo Shin
Sep 14, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Mingkwan Na TakuathungSeewaboon Sireeratawong
Aug 16, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Bumjung KimKyungjin Lee
Jul 27, 2018·BioMed Research International·Bo-Kyung ParkMi Young Lee
Feb 1, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Thien T P DaoYeong Shik Kim
May 7, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Bo-Kyung ParkMi Young Lee
Oct 15, 2019·Frontiers in Pharmacology·So Min LeeJeeyoun Jung
Jul 25, 2021·International Journal of Molecular Sciences·Wonmin KoDong-Sung Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here