Anti-inflammatory actions of pentacyclic triterpenes

Planta medica
H Safayhi, E R Sailer

Abstract

Pentacyclic triterpenes (PTs) as aglycones of saponins have a wide distribution in plants, and many of them have been used as anti-inflammatory remedies in folk medicine. This survey critically reviews the effects of PTs on proinflammatory mediator signalling pathways and data from experimental animal models and clinical trials. Because the knowledge of their actions is far from being satisfactory a critical summary of the partly promising but mostly scattered and preliminary data might promote productive research on chances and risks of PTs. Antiproliferative and anti-infectious actions and effects on intracellular cell signalling and hormone metabolism are beyond the scope of this short review, although such effects might also contribute to the understanding of the systemic anti-inflammatory actions of aglycones.

Citations

May 21, 2005·Journal of Ethnopharmacology·Glauce N SilvaPatricia D Fernandes
Jul 14, 2001·Fitoterapia·E L Ghisalberti
Jan 30, 2002·Journal of Pharmaceutical and Biomedical Analysis·Leena Suntornsuk
May 15, 2002·Journal of Pharmaceutical and Biomedical Analysis·Astrid KaunzingerManfred Schubert-Zsilavecz
Oct 31, 2013·Journal of Asian Natural Products Research·Xiu-Lan XinYing-Hua Xiong
Sep 11, 2010·Journal of Medicinal Food·Ellen Tanus-RangelDomingos T O Martins
Nov 23, 2006·Neurosurgical Focus·Joseph C MaroonNathan A Ross
Jan 6, 2011·Surgical Neurology International·Joseph C MaroonAdara Maroon
Jan 10, 2002·Biochemical and Biophysical Research Communications·Anja AltmannOliver Werz
Jan 26, 2011·Journal of Young Pharmacists : JYP·Ma PatelMb Patel
Dec 14, 2007·Natural Product Research·Cristina Gaspar-MarquesBenjamín Rodríguez
Jul 14, 1999·Archives of Pharmacal Research·S Y KimH P Kim
Aug 19, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·E M WenzigR Bauer
Jun 17, 2014·Journal of Ethnopharmacology·Ruberlei Godinho de OliveiraDomingos Tabajara de Oliveira Martins
Oct 13, 2015·Journal of the Science of Food and Agriculture·Qudeer Ahmed AbdulJae Sue Choi
Feb 9, 2007·Life Sciences·Jarbas Mota SiqueiraRosa Maria Ribeiro-do-Valle
Feb 27, 2010·Dermatologic Therapy·Piergiacomo Calzavara-PintonAlessandra Pedretti
Nov 26, 2015·BMC Complementary and Alternative Medicine·Sarbani Dey RaySaikat Dewanjee
Apr 20, 2006·Journal of Ethnopharmacology·Norihiro BannoTakashi Suzuki
Dec 3, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Abdur RaufAbdul Wadood
Dec 21, 2010·Biochimica Et Biophysica Acta·Jesús PradesFrancisca Barceló

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