Anti-inflammatory activities and potential mechanisms of phenolic acids isolated from Salvia miltiorrhiza f. alba roots in THP-1 macrophages

Journal of Ethnopharmacology
Haimei LiuLongru Sun

Abstract

The roots of Salvia miltiorrhiza f. alba (Lamiaceae) (RSMA) are used as the Danshen, a traditional Chinese medicine, to treat the vascular diseases at local clinics, especially for the remedy of thromboangiitis obliterans (TAO) more than 100 years. Phenolic acids are one of the major effective constituents of RSMA, and some studies have linked phenolic acids with anti-inflammatory functions. The purpose of this research was to isolate phenolic acids from RSMA and investigate their anti-inflammatory effects and potential mechanisms. Nine already known compounds were obtained from RSMA. Their structures were elucidated through the spectroscopic analysis and comparing the reported data. The anti-inflammatory effects and potential mechanisms were investigated in LPS-stimulated THP-1 cells, using salvianolic acid B (SalB) as the positive control. The enzyme-linked immunosorbent assays (ELISA) were used to determine the secretory protein levels of interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). And quantitative real-time polymerase chain reaction (qRT-PCR) was used to analyze the mRNA levels of these inflammatory cytokines. The expression of TLR4, p65, p-p65, IκBα, and p-IκBα were measured using west...Continue Reading

Citations

Jun 2, 2020·Biological & Pharmaceutical Bulletin·Yuanyuan ZhangLi Chu
Dec 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrea F AfonsoSusana M Cardoso
Nov 27, 2020·Journal of Ethnopharmacology·Thaíse Gabriele da Silva BritoVera Lúcia de Menezes Lima
Apr 22, 2021·BMC Complementary Medicine and Therapies·Abbas RaisiSoroush Afshar Ghahremani

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