Anti-inflammatory activity and molecular mechanism of delphinidin 3-sambubioside, a Hibiscus anthocyanin

BioFactors
Takayuki SogoDe-Xing Hou

Abstract

Delphinidin 3-sambubioside (Dp3-Sam), a Hibiscus anthocyanin, was isolated from the dried calices of Hibiscus sabdariffa L, which has been used for folk beverages and herbal medicine although the molecular mechanisms are poorly defined. Based on the properties of Dp3-Sam and the information of inflammatory processes, we investigated the anti-inflammatory activity and molecular mechanisms in both cell and animal models in the present study. In the cell model, Dp3-Sam and Delphinidin (Dp) reduced the levels of inflammatory mediators including iNOS, NO, IL-6, MCP-1, and TNF-α induced by LPS. Cellular signaling analysis revealed that Dp3-Sam and Dp downregulated NF-κB pathway and MEK1/2-ERK1/2 signaling. In animal model, Dp3-Sam and Dp reduced the production of IL-6, MCP-1 and TNF-α and attenuated mouse paw edema induced by LPS. Our in vitro and in vivo data demonstrated that Hibiscus Dp3-Sam possessed potential anti-inflammatory properties.

References

Sep 23, 1994·Cell·C Nathan, Q W Xie
Nov 1, 1994·Trends in Biochemical Sciences·R J Davis
Mar 10, 2001·Nature·L Chang, M Karin
Jan 5, 2002·Journal of Agricultural and Food Chemistry·Yasuko NodaLester Packer
Oct 3, 2002·Biochemical and Biophysical Research Communications·John J Haddad
Mar 13, 2003·Current Molecular Medicine·De-Xing Hou
Jul 12, 2003·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Hiromi NagaiTetsu Takahashi
Dec 4, 2003·Cancer Letters·Peter KubatkaMartina Marková
Jan 7, 2004·Journal of Agricultural and Food Chemistry·Tony K McGhieDwayne J Jensen
Jan 5, 2005·BioFactors·Takashi IchiyanagiTetsuya Konishi
Feb 3, 2005·Cell Research·Zheng Gang Liu
Apr 19, 2005·European Journal of Nutrition·Jens FleschhutSabine E Kulling
Aug 31, 2006·Journal of Agricultural and Food Chemistry·Takashi IchiyanagiTetsuya Konishi
Dec 22, 2006·Nature Reviews. Molecular Cell Biology·Neil D Perkins
May 30, 2007·Molecular Nutrition & Food Research·Tony K McGhie, Michaela C Walton
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Gautam SethiBharat B Aggarwal
Nov 1, 2011·Toxicology and Applied Pharmacology·Irene CuadradoSonsoles Hortelano
Jan 24, 2014·SpringerPlus·Prati Pal Singh, Amit Goyal

❮ Previous
Next ❯

Citations

Oct 16, 2015·Critical Reviews in Food Science and Nutrition·Baiyi LuRan Yin
Nov 3, 2016·Oxidative Medicine and Cellular Longevity·Palanisamy ArulselvanS Suresh Kumar
Dec 5, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Qin LiXin Hua Liu
Nov 13, 2018·Current Medicinal Chemistry·Antonio SpecialeMariateresa Cristani
Jul 20, 2016·International Journal of Molecular Medicine·Jae-Won LeeKyung-Seop Ahn
Jun 14, 2019·Frontiers in Plant Science·Georgianna K OguisDavid J Craik
Feb 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·María Del Carmen Villegas-AguilarAntonio Segura-Carretero
Feb 4, 2021·Journal of Food Biochemistry·Ganesamoorthy JanarnyKamburawala Kankanamge Don Somathilaka Ranaweera
May 6, 2021·International Wound Journal·Pamela Viaña-MendietaJorge Benavides
May 7, 2021·Environmental Toxicology·Zhiyong ZhangShuixiang He
Jun 8, 2021·Critical Reviews in Food Science and Nutrition·Sajad FakhriHaroon Khan
Jul 3, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Teerasak DamrongrungruangAroonsri Priprem
Sep 27, 2019·Journal of Agricultural and Food Chemistry·Zhixi ChenLonghuo Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here