Anti-inflammatory Activity and Phytochemical Profile of Galinsoga Parviflora Cav

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Elżbieta Studzińska-SrokaJanusz Witowski

Abstract

The objective of this study was to evaluate the usefulness of a hydroalcoholic extract from Galinsoga parviflora herb (GP) in some aspects of the endothelial cell function necessary for anti-inflammatory activity and wound healing and relate these to the GP phytochemical profile. This study demonstrated that the GP extract caused a dose-dependent reduction of IL-6 secretion on IL-1β-stimulated endothelial cells. The IL-6 release was decreased to 33% ± 9% while this did not influence the IL-6 secretion without stimulation. Additionally, the GP extract exhibited an anti-hyaluronidase activity (IC50 = 0.47 mg/mL), which was evidently stronger than the positive control kaempferol (IC50 = 0.78 mg/mL) as well as a moderate and concentration-dependent, antioxidant activity. The results of the scratch assay showed that exposure of the endothelial cells to GP induced complete healing of the damage after 12 h of the study. The phytochemical profile of the extract was studied by using spectrophotometric (total amount of polyphenols and flavonoids) and UPLC (phenolic acids) methods. The main compound in the GP extract was a chlorogenic acid (2.00 ± 0.01 mg/g by UPLC). The total content of polyphenols was 98.30 ± 0.14 mg of chlorogenic acid...Continue Reading

References

Dec 1, 1990·The Journal of Endocrinology·E E Anggård
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C J EdgellJ B Graham
Aug 10, 1999·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·C M SimõesL Girre
Jun 6, 2000·Journal of Ethnopharmacology·F A HamillD D Soejarto
Jun 6, 2003·Journal of Ethnopharmacology·Esther N Matu, Johannes van Staden
Nov 2, 2006·Biological & Pharmaceutical Bulletin·Michel David dos SantosGlória Emília Petto de Souza
Jan 24, 2007·Journal of Ethnopharmacology·M F AgraV P M Coelho
May 12, 2009·Journal of Ethnopharmacology·C SchmidtI Merfort
Sep 24, 2009·Journal of Enzyme Inhibition and Medicinal Chemistry·Sadia FerheenRasool Bakhsh Tareen
Mar 18, 2010·Journal of Enzyme Inhibition and Medicinal Chemistry·Changwei AoShinkichi Tawata
Aug 21, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Katarzyna KorybalskaJanusz Witowski
Sep 4, 2012·International Journal of Molecular Sciences·Ana P TiveronSeverino M Alencar
Oct 16, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Su Jung HwangKyu-Won Kim
Mar 1, 2012·Preventive Nutrition and Food Science·Jeonghee Surh, Jung-Mi Yun
Aug 9, 2016·BMC Complementary and Alternative Medicine·Manoela Torres-RêgoMatheus de Freitas Fernandes-Pedrosa
Sep 9, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sara E MoghadamEhsan Jabbarzadeh
May 8, 2018·Drug Development Research·Eman Al-Sayed, Mohamed M Abdel-Daim

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Citations

Dec 26, 2019·Scientific Reports·Renata Zawirska-WojtasiakSylwia Mildner-Szkudlarz
Aug 3, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Félicien Mushagalusa KasaliJustin Ntokamunda Kadima

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Methods Mentioned

BETA
Assay
Protein Assay
column chromatography
FACS

Software Mentioned

Empower
AxioVision
GraphPad
Graph Pad
FACS Diva
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