Anti-inflammatory activity of a new class of nitric oxide synthase inhibitors that release nitric oxide

ChemMedChem
Maurizio BottaS Fiorucci

Abstract

Nitric oxide (NO) is a gaseous mediator that exerts key regulatory functions in mammalian cells. Low levels of NO exert homeostatic functions and counteract inflammation, whereas high amounts of NO cause tissue destruction and cellular death. Herein we describe a new class of nitric oxide synthase (NOS) inhibitor NO-donating drugs (NI-NODs). Human endothelial cells and human monocyte-based activity screening showed that NI-NODs inhibit IL-1beta production, modulate PGE(2) production, and protect against apoptosis. In a rodent model of colitis, NI-NOD1 and NI-NOD2 potently decreased inflammation. These data show that NI-NODs are effective in both in vitro and in vivo models of inflammation, mimicking the positive effects of low levels of NO and suppressing NOS-induced NO production.

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Citations

Jun 11, 2011·Chemical Reviews·Daniele CastagnoloMaurizio Botta
Nov 29, 2015·Chinese Journal of Natural Medicines·Xiao-Lan ChengE-Hu Liu
Jun 25, 2016·Beilstein Journal of Organic Chemistry·Sean P BewClaire E Reeves
Nov 7, 2019·Oxidative Medicine and Cellular Longevity·Cristian Cezar LoginŞoimiţa Suciu

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