Anti-inflammatory activity of chitooligosaccharides in vivo.

Marine Drugs
João FernandesJoão E Carvalho

Abstract

All the reports to date on the anti-inflammatory activity of chitooligosaccharides (COS) are mostly based on in vitro methods. In this work, the anti-inflammatory activity of two COS mixtures is characterized in vivo (using balb/c mice), following the carrageenan-induced paw edema method. This is a widely accepted animal model of acute inflammation to evaluate the anti-inflammatory effect of drugs. Our data suggest that COS possess anti-inflammatory activity, which is dependent on dose and, at higher doses, also on the molecular weight. A single dose of 500 mg/kg b.w. weight may be suitable to treat acute inflammation cases; however, further studies are needed to ascertain the effect upon longer inflammation periods as well as studies upon the bioavailability of these compounds.

References

Apr 1, 1990·Chemical & Pharmaceutical Bulletin·Y Ozaki
Apr 25, 2000·Biochemical and Biophysical Research Communications·S M HwangJ C Chen
Sep 9, 2000·Current Opinion in Cell Biology·J Y Lee, A P Spicer
Apr 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A R ShikhmanM Lotz
Dec 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·C A WINTERG W NUSS
Jul 19, 2005·Journal of Ethnopharmacology·C RujjanawateS Pojanagaroon
Nov 24, 2005·Journal of Ethnopharmacology·James B PerianayagamK K Pillai
Mar 20, 2008·Laboratory Animals·UNKNOWN Joint Working Group on Veterinary CareS Wolfensohn
Aug 30, 2008·Journal of Ethnopharmacology·Kyung-Hee Lee, Eun-Mi Choi
Nov 13, 2008·Biomacromolecules·João C FernandesF Xavier Malcata

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Citations

Nov 12, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jung-Hyun KimPyo-Jam Park
Jan 17, 2015·Journal of Functional Biomaterials·Kazuo AzumaYoshiharu Okamoto
Apr 6, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mohammad YousefChatchai Muanprasat
Apr 5, 2016·Parasitology Research·Mahmoud Abdel-LatifAbdel-Azeem S Abdel-Baki
Feb 17, 2015·Journal of Biomedical Materials Research. Part a·Steinunn GudmundsdottirPetur H Petersen
Apr 12, 2014·BioMed Research International·Gaurav LodhiPyo-Jam Park
Mar 26, 2015·PloS One·Chistiane Oliveira CouraNorma Maria Barros Benevides
Oct 30, 2016·Pharmacology & Therapeutics·Chatchai Muanprasat, Varanuj Chatsudthipong
Oct 4, 2012·Acta Cirúrgica Brasileira·Bulent CitgezOguzhan Karatepe
May 31, 2018·Animal : an International Journal of Animal Bioscience·J R GerezA P F R Loureiro Bracarense
Apr 7, 2015·Journal of Atherosclerosis and Thrombosis·Yang YuShucun Qin
Jan 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jiao ZhangJun He
Oct 26, 2018·Emerging Topics in Life Sciences·Meixi LingLong Liu
Mar 27, 2021·Carbohydrate Polymers·Nishat TabassumM Azam Ali
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yujie WangYuguang Du
Aug 10, 2021·Preparative Biochemistry & Biotechnology·Julia Maria de Medeiros DantasEveraldo Silvino Dos Santos
Jul 10, 2017·ACS Biomaterials Science & Engineering·Lina PapadimitriouMaria Chatzinikolaidou
Nov 2, 2021·Journal of Biomedical Materials Research. Part a·Ysander von BoxbergFatiha Nothias

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Software Mentioned

Statistical Package for Social Sciences – SPSS

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