Anti-inflammatory activity of essential oil from leaves of Myrciaria tenella and Calycorectes sellowianus

Pharmaceutical Biology
Miriam A ApelPaulo Roberto H Moreno

Abstract

The GC-MS analysis revealed that the leaf essential oils of Myrciaria tenella (DC.) Berg and Calycorectes sellowianus O. Berg (Myrtaceae) were composed of 34 and 37 compounds, respectively. The main constituents of M. tenella oil were beta-caryophyllene (25.1%), and spathulenol (9.7%), while for C. sellowianus were guaiol (13.1%) and beta-caryophyllene (8.6%). The anti-inflammatory effect of both essential oils was investigated in vitro and in vivo. Both oils reduced significantly (p < 0.005) the treated neutrophils chemotaxis with 93% and 91% inhibition for M. tenella and C. sellowianus, respectively. However, in the systemic treatment with the essential oils (50 mg/kg p.o.) only the M. tenella oil was able to significantly reduce the carrageenan-induced paw edema with a similar effect to that observed for indomethacin (10 mg/kg), the positive control.

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Citations

Dec 17, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Graça Miguel
May 14, 2020·Advances in Pharmacological and Pharmaceutical Sciences·Izabelly Bianca da Silva SantosMárcia Vanusa da Silva
Aug 25, 2019·Antioxidants·Ana Raquel Carneiro RibeiroKátia Castanho Scortecci
Mar 5, 2017·Journal of Leukocyte Biology·Gulmira ÖzekMark T Quinn

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