Anti-inflammatory activity of roots of Cichorium intybus due to its inhibitory effect on various cytokines and antioxidant activity

Ancient Science of Life
Waseem RizviAnil Kumar

Abstract

Cichorium intybus L. commonly known as chicory is one of the important medicinal plants commonly used in Ayurvedic system of medicine. It is commonly used for the treatment of diseases involving a khapa and pitta doshas. Traditionally, C. intybus is used for the treatment of inflammatory conditions, but there are only few in vitro studies reporting the anti-inflammatory activity of roots of chicory. Evaluation of anti-inflammatory activity of roots of chicory and mechanisms involved in it using in vivo models of inflammation. Albino Wistar rats of either sex weighing 150-200 g were used. Ethanolic and aqueous extracts of roots of chicory were prepared with the help of Soxhlet's apparatus. The anti-inflammatory activity was studied using carrageenan-induced paw edema method and cotton pellet granuloma method. Levels of cytokines such as tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and IL-1 and activity of antioxidant enzymes such as catalase (CAT) and glutathione peroxidase (GPx) were estimated. Chicory roots demonstrated significant dose-dependent decrease in paw edema in carrageenan-induced paw edema method. Chicory roots diminished the serum TNF-α, IL-6, and IL-1 levels. They also significantly attenuated the ma...Continue Reading

Citations

Oct 23, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Seyed Hamdollah MosavatMahdie Hajimonfarednejad
Jan 1, 2020·Environmental Science and Pollution Research International·Samia Mostafa Mohamed Mohafrash, Abdel-Tawab Halim Mossa
Feb 4, 2019·The Journal of Physiological Sciences : JPS·Farkhonde HasannejadBehrooz Khakpour Taleghani
Oct 9, 2019·International Journal of Molecular Sciences·Yu WangTing Yang
Sep 16, 2020·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Mohammad Raman MoloudiEsmael Izadpanah
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katarzyna JandaKarolina Jakubczyk

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