PMID: 9174976Apr 1, 1997Paper

Anti-inflammatory activity of Salacia oblonga Wall. and Azima tetracantha Lam

Journal of Ethnopharmacology
T S IsmailV Elango

Abstract

The anti-inflammatory activity of Salacia oblonga rootbark powder and Azima tetracantha leaf powder was assayed in male albino rats using carrageenan-induced rat paw oedema (acute inflammation) and cotton pellet granuloma (chronic inflammation) methods. Both the crude drugs were maximally active at a dose of 1000 mg/kg. In the cotton pellet granuloma assay, these drugs were able to suppress the transudative, exudative and proliferative components of chronic inflammation. Furthermore, these drugs were able to lower the lipid peroxide content of exudate and liver, gamma-glutamyl transpeptidase activity in the exudate of cotton pellet granuloma. The increased acid and alkaline phosphatase activity and decreased serum albumin in cotton pellet granulomatous rats were normalised after treatment with these drugs. It is likely that these drugs may exert their activity by antiproliferative, antioxidative and lysosomal membrane stabilization.

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Citations

Mar 12, 2004·Journal of Ethnopharmacology·Victor B OwoyeleSamuel B Olaleye
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Feb 2, 2012·Natural Product Research·Marcus Vinícius M NascimentoElson Alves Costa
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Jan 1, 2011·Journal of Basic and Clinical Physiology and Pharmacology·Samuel A OnasanwoAdebowale B Saba
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Nov 26, 2015·BMC Complementary and Alternative Medicine·Sarbani Dey RaySaikat Dewanjee
Nov 26, 2015·Physiology and Molecular Biology of Plants : an International Journal of Functional Plant Biology·Anjaneyulu MusiniArchana Giri
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Dec 4, 2020·Journal of Ethnopharmacology·Christudas SunilSavarimuthu Ignacimuthu

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