Anti-inflammatory activity of Trichosanthes cucumerina Linn. in rats

Journal of Ethnopharmacology
Menuka ArawwawalaS M Handunnetti

Abstract

Trichosanthes cucumerina Linn. (Family: Cucurbitaceae) is one of the medicinal plants that is often used in Sri Lankan traditional systems of medicine. One of its uses is the treatment of inflammatory conditions. However, validity of the anti-inflammatory activity has not been scientifically investigated so far. Therefore, the aim of this study was to investigate the anti-inflammatory potential of Trichosanthes cucumerina hot water extract (HWE) and its fractions. The anti-inflammatory activity of Trichosanthes cucumerina was evaluated by use of the carrageenan-induced paw oedema model in Wistar rats. In addition, the mechanism/s by which Trichosanthes cucumerina is mediated the anti-inflammatory activity was assessed by determining its effects on (a) membrane stabilizing activity and (b) nitric oxide inhibitory activity. Apart from the lowest dose of the HWE, other tested doses (500, 750, 1000 mg/kg) produced a significant (P ≤ 0.05) inhibition of the inflammation, most pronounced at 5h after the injection of carrageenan. The anti-inflammatory effect induced by 750 mg/kg, was comparable to that of the reference drug, indomethacin at 4 and 5h. Inhibition of nitric oxide (NO) production and membrane stabilization activities are ...Continue Reading

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Citations

Sep 27, 2014·BMC Complementary and Alternative Medicine·Sook Shien LeeSzu Ting Ng
Jan 7, 2014·Journal of Ethnopharmacology·K D K P KumariT S Suresh
Nov 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Letizia PolitoAndrea Bolognesi
Jan 25, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ren Jye LimLi Xu
Jun 16, 2017·BMC Complementary and Alternative Medicine·Ramani KarunakaranL D A Menuka Arawwawala
Mar 28, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·W J A Banukie N JayasuriyaT Sugandhika Suresh
Dec 21, 2016·International Journal of Food Science·Ruvini LiyanageSwarna Wimalasiri
Sep 4, 2020·Menopause : the Journal of the North American Menopause Society·Yu-Jung ChungTzung-Yi Tsai

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