Anti-inflammatory and analgesic effects of cucurbitacins from Wilbrandia ebracteata

Planta medica
R R PetersRosa Maria Ribeiro-do-Valle

Abstract

The anti-inflammatory and antinociceptive actions of the CH2Cl2 extract and semipurified fraction (F-III) from roots of Wilbrandia ebracteata Cogn. have been investigated in rats and mice. The CH2Cl2 extract (1-10 mg/kg, i.p.; ID50 5 mg/kg) and (3-30 mg/kg, p.o.; ID50 15 mg/kg) inhibited, in a dose-related manner, carrageenan-induced paw edema in rats. The subfraction (F-III) from CH2Cl2 extract and compounds isolated as cucurbitacin B and E also inhibited carrageenan-induced edema. The CH2Cl2 extract and F-III also exhibited significant analgesic action in acetic acid-induced pain in mice. In the formalin test, the CH2Cl2 extract (0.3-10 mg/kg, i.p.) and (3-30 mg/kg, p.o.) caused inhibition of the neurogenic (first phase) and inflammatory phase (second phase) of formalin-induced pain. However, the CH2Cl2 extract was more effective in relation to the second phase than in inhibition of the formalin-induced edema. These findings suggest that CH2Cl2 extract has potent anti-inflammatory and analgesic action and that F-III and cucurbitacin B and E may account for these actions.

Citations

Nov 26, 2002·Cancer Letters·Bolleddula JayaprakasamMuraleedharan G Nair
Jul 7, 2011·International Journal of Molecular Sciences·Gedson Rodrigues de Morais LimaLeônia Maria Batista
Feb 3, 2009·Cancer Chemotherapy and Pharmacology·Jarbas Mota SiqueiraRosa Maria Ribeiro-do-Valle
Jan 31, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Jing QiaoXian-hui He
Feb 24, 2011·Journal of Cellular Biochemistry·Hong Ri JinJung Joon Lee
Aug 24, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·T Wegener, H Wagner
Mar 28, 2006·Journal of Ethnopharmacology·Geisson Marcos NardiRosa Maria Ribeiro-do-Valle
May 9, 2002·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Fabiana G Gonzalez, Luiz C Di Stasi
Jun 12, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Siddig Ibrahim AbdelwahabA Hamid A Hadi
Feb 9, 2007·Life Sciences·Jarbas Mota SiqueiraRosa Maria Ribeiro-do-Valle
Feb 14, 2004·Organic Letters·Christoph SegerHermann Stuppner
Jul 13, 2005·Natural Product Reports·Jian Chao ChenSamuel X Qiu
Dec 21, 2016·Journal of Chromatographic Science·Yaxin LiAimin Zhou
Jul 6, 2019·BMC Complementary and Alternative Medicine·Natthaphon HunsakunachaiPhisit Khemawoot
Nov 16, 2017·International Journal of Oncology·Sukant GargRenu Wadhwa
Apr 24, 2018·Oxidative Medicine and Cellular Longevity·Dong Kwon Yang, Shang-Jin Kim
Aug 7, 2021·Saudi Journal of Biological Sciences·Shahana WahidRafeeq Alam Khan
Apr 5, 2011·Bioorganic & Medicinal Chemistry·Judit Bartalis, Fathi T Halaweish

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