Anti-inflammatory and analgesic potency of carboxyamidotriazole, a tumorostatic agent

The Journal of Pharmacology and Experimental Therapeutics
Lei GuoDechang Zhang

Abstract

Carboxyamidotriazole (CAI) is a calcium influx inhibitor that is undergoing clinical trials for the treatment of various human cancers following the identification of its antiproliferative and antimetastatic activities. The exact mechanism of its action is not clearly understood, and whether it has other functions besides the established antitumor activity has not been reported either. In the present study, we demonstrate for the first time that CAI possesses anti-inflammatory and analgesic activities using a variety of animal models, including croton oil-induced ear edema, cotton-induced granuloma, rat adjuvant-induced arthritis, acetic acid-induced writhing, and the formalin test. We also show that CAI significantly inhibits local vascular permeability stimulated by vascular endothelial growth factor or histamine and decreases tumor necrosis factor-alpha and interleukin-1beta levels at the site of inflammation and in serums, which may contribute to the anti-inflammatory effect. These data suggest that CAI is a promising anti-inflammatory and analgesic agent, and they provide new insight into the biological activity of the drug.

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Citations

Aug 27, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Nayrton Flávio Moura RochaFrancisca Cléa Florenço de Sousa
Jul 23, 2013·Chemico-biological Interactions·Nayrton Flávio Moura RochaFrancisca Cléa Florenço de Sousa
Dec 3, 2014·European Journal of Pharmacology·Lei GuoDechang Zhang
Jul 20, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Rui JuDechang Zhang
Jan 27, 2017·Naunyn-Schmiedeberg's Archives of Pharmacology·Chen ChenLei Guo
Sep 13, 2019·Journal for Immunotherapy of Cancer·Jing ShiDechang Zhang
Oct 31, 2009·Immunopharmacology and Immunotoxicology·Masami OgawaChiaki Kamei

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