Anti-inflammatory and anti-fibrotic effects of intravenous adipose-derived stem cell transplantation in a mouse model of bleomycin-induced interstitial pneumonia

Scientific Reports
Takuya KotaniMasaaki Ii

Abstract

Adipose-derived stem cells (AdSCs) have recently been considered a useful treatment tool for autoimmune disease because of their anti-inflammatory and immunosuppressive effects. We investigated the therapeutic effect of intravenous AdSC transplantation in a mouse model of bleomycin-induced lung injury. AdSCs accumulated in the pulmonary interstitium and inhibited both inflammation and fibrosis in the lung, markedly improving the survival rate of mice with bleomycin-induced lung injury in a cell number-dependent manner. AdSCs inhibited the production of pro-inflammatory cytokines such as TNF-α and IL-12 in activated macrophages, and AdSCs also induced the apoptosis of activated macrophages. AdSCs inhibited the differentiation and proliferation of Th2-type mCD4+ T cells but promoted the differentiation and proliferation of regulatory T cells, suggesting that the phenotypic conversion of T cells may be one of the mechanisms for the anti-inflammatory effect of AdSCs on pulmonary fibrosis. These findings suggest that intravenous AdSCs could be a promising treatment for patients with interstitial pneumonia.

References

Jun 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Luis A OrtizDonald G Phinney
Jul 2, 2003·Cells, Tissues, Organs·Daniel A De UgarteMarc H Hedrick
May 14, 2005·American Journal of Respiratory Cell and Molecular Biology·Mauricio RojasKenneth L Brigham
May 15, 2008·BioTechniques·Ralf-Harto HübnerBurkhard Bewig
Mar 28, 2009·The European Respiratory Journal·M KumamotoK Matsushima
Jun 6, 2009·The American Journal of Pathology·Yuben MoodleyAlan Trounson
Aug 17, 2010·American Journal of Respiratory and Critical Care Medicine·Kelly S SchweitzerIrina Petrache
Sep 22, 2011·Microscopy Research and Technique·Rosa M CabralMaria A Miglino
Jul 18, 2012·Proceedings of the American Thoracic Society·Katrina McNulty, Sam M Janes
Dec 5, 2012·Respiration; International Review of Thoracic Diseases·Rebecca LimGraham Jenkin
Dec 12, 2012·Nature Biotechnology·David Cyranoski
Jan 15, 2013·Biochemical and Biophysical Research Communications·Kohei TatsumiTeruo Okano
Mar 9, 2013·Journal of the American Society of Nephrology : JASN·Kazuhiro FuruhashiShoichi Maruyama
Jul 17, 2013·American Journal of Respiratory and Critical Care Medicine·Daniel J Weiss, Luis A Ortiz
May 20, 2014·The New England Journal of Medicine·Luca RicheldiUNKNOWN INPULSIS Trial Investigators
May 20, 2014·The New England Journal of Medicine·Talmadge E KingUNKNOWN ASCEND Study Group
Oct 4, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Jun TashiroMarilyn K Glassberg
Jul 23, 2016·British Journal of Pharmacology·Anandharajan RathinasabapathyMichael J Katovich
Nov 24, 2016·Alimentary Pharmacology & Therapeutics·C GrégoireY Beguin

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Citations

Mar 5, 2019·Journal of Gastroenterology and Hepatology·Masatoshi YamatoShuichi Kaneko
Nov 24, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Ryoichi UchimuraYasuhiko Itoh
Sep 5, 2019·Current Stem Cell Research & Therapy·Xiang HeDahai Hu
Feb 27, 2019·Plastic and Reconstructive Surgery·Ki Yong HongHak Chang
Aug 15, 2018·Medical Sciences : Open Access Journal·Anna Serrano-Mollar
Jan 27, 2019·Stem Cell Research & Therapy·Jing WangJunrong Cai
Apr 7, 2021·Aesthetic Surgery Journal·Hongli ZhaoSai Luo
Jun 21, 2021·Stem Cell Research & Therapy·Junling GaoZhongbing Lu

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Methods Mentioned

BETA
PCR

Software Mentioned

WinROOF
GraphPad Prism

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