Anti-inflammatory and Anti-osteoporotic Potential of Lactobacillus plantarum A41 and L. fermentum SRK414 as Probiotics.

Probiotics and Antimicrobial Proteins
Chul Sang Lee, Sae Hun Kim

Abstract

This study involves an investigation on the probiotic properties of lactic acid bacteria and their potential applications in an in vitro model of lipopolysaccharide (LPS)-stimulated inflammation and dexamethasone-induced osteoporosis. Nine strains were pre-screened from 485 lactic acid bacteria based on their survival at a low pH and in a solution containing bile salts. All candidates were capable of surviving in an environment with low pH and with bile salts and could successfully colonize the intestine. Furthermore, their functional properties, such as anti-oxidation and anti-inflammation, were evaluated. Of the nine probiotic candidates, Lactobacillus plantarum A41 and L. fermentum SRK414 exhibited the highest anti-oxidative capacity. Moreover, only L. plantarum A41 and L. fermentum SRK414 could increase gut barrier function by upregulating the mRNA expression of tight junction proteins and inhibit the expression of inflammatory mediators induced by LPS-stimulated inflammation. Interestingly, these two strains were also capable of regulating several bone metabolism-related markers playing a role in bone homeostasis and osteoblast differentiation. In brief, L. plantarum A41 and L. fermentum SRK414 exhibited high probiotic pot...Continue Reading

References

Jul 1, 1989·Applied and Environmental Microbiology·G W TannockS D Feighner
Jun 26, 2002·Proceedings of the National Academy of Sciences of the United States of America·Lovisa HessleJosé Luis Millan
Oct 2, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alan S FanningJames Melvin Anderson
Nov 1, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Minna K SalminenAsko Järvinen
Jan 26, 2005·The Journal of Clinical Investigation·Shi WeiSteven L Teitelbaum
Aug 19, 2007·Cell·Na Kyung LeeGerard Karsenty
Oct 16, 2007·Digestive Diseases and Sciences·Iryna B SorokulovaMaria C Urdaci
Apr 15, 2009·European Journal of Nutrition·Maria Cristina VerdenelliAlberto Cresci
Mar 13, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jurgen KarczewskiJerry M Wells
Jan 29, 2011·World Journal of Gastroenterology : WJG·David PhilippeStéphanie Blum
Nov 22, 2011·Nature Reviews. Microbiology·Peter A BronMichiel Kleerebezem
Oct 3, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Yan J JiangDaniel D Bikle
Dec 4, 2012·Food Microbiology·Anthoula A ArgyriChrysoula C Tassou
Jan 16, 2013·Applied Microbiology and Biotechnology·Shen-Shih Chiang, Tzu-Ming Pan
Mar 19, 2014·PloS One·Claes OhlssonKlara Sjögren
Dec 17, 2014·Trends in Endocrinology and Metabolism : TEM·Claes Ohlsson, Klara Sjögren
Mar 27, 2015·Journal of Agricultural and Food Chemistry·Vijendra MishraJashbhai Prajapati
Aug 4, 2015·Frontiers in Microbiology·Natallia V VarankovichDarren R Korber
Sep 12, 2015·Biochemical and Biophysical Research Communications·Yuekui JianXiaobin Tian
Aug 26, 2017·Microbiology Spectrum·Fraser L CollinsLaura R McCabe

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Citations

Apr 4, 2021·Nutrients·María Jesús Rodríguez-SojoAlba Rodríguez-Nogales
May 4, 2021·Comprehensive Reviews in Food Science and Food Safety·Jie GaoYaxin Sang
May 8, 2021·Probiotics and Antimicrobial Proteins·Chul Sang LeeSae Hun Kim
May 26, 2021·Regenerative Medicine·Farzaneh AavaniAbolfazl Nazbar
Jun 3, 2021·International Journal of Molecular Sciences·Gayoung KimDae-Kyun Chung
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Matteo Dell'AnnoLuciana Rossi

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