Anti-inflammatory and antinociceptive activity of arbortristoside-A

Journal of Ethnopharmacology
Sanjita DasSaumya Priya Basu

Abstract

Nyctanthes arbortristis Linn is a well-documented plant. It is evident from literature and previous investigations that Nyctanthes arbortristis possesses anti-inflammatory and analgesic activity. In the present study arbortristoside-A has been isolated from the ethanolic extract of its seeds. The structure of the isolated compound was determined by chemical reactions and spectroscopic methods. Arbortristoside-A was found to possess significant and dose-dependent anti-inflammatory and antinociceptive activity. It seems arbortristoside-A inhibited the histamine, serotonin and carrageenan-induced edema suggesting its inhibiting effect on carrageenan, arachidonic acid, histamine and serotonin-induced edema suggesting its anti-inflammatory activity may be due to the inhibiting effect of prostaglandin, histamine and serotonin. The analgesic activity of arbortristoside-A may be due to the inhibition of the action of prostaglandin.

References

Jul 1, 1991·Journal of Natural Products·J S TandonP Y Guru
Dec 4, 2003·Bioorganic & Medicinal Chemistry·R C MishraR P Tripathi

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Citations

Dec 29, 2012·North American Journal of Medical Sciences·Priyanka JadhavNilima Kshirsagar
Dec 19, 2012·Journal of Pharmacy & Bioallied Sciences·S Meghashri, S Gopal
Oct 1, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Sukanya PandetiNarender Tadigoppula
Jun 12, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Vaibhav MishraTadigoppula Narender
Feb 5, 2013·Journal of Ethnopharmacology·Jyoti Agrawal, Anirban Pal
Aug 19, 2011·Pharmaceutical Biology·J A Moreno-EscobarV Rodríguez-López
Jan 16, 2018·Rapid Communications in Mass Spectrometry : RCM·Sukanya PandetiJagadeshwar Reddy Thota

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