Anti-inflammatory and antioxidant activity of polyphenolic extracts from Lactuca sativa (var. Maravilla de Verano) under different farming methods

Journal of the Science of Food and Agriculture
Simona AdessoStefania Marzocco

Abstract

Besides their nutritional value, vegetables are a source of health-promoting compounds, such as polyphenols, and their content can be influenced by the particular farming method. In this study polyphenolic extracts from Lactuca sativa (var. Maravilla de verano) plants cultivated with different farming methods were chemically characterised and tested in vitro and ex vivo inflammation models. The tested extacts (250-2.5 µg mL(-1) ) were able to reduce both the inflammatory and oxidative stress in LPS-stimulated J774A.1 murine monocyte macrophage cells, by lowering the release of nitric oxide (NO) and reactive oxygen species (ROS) and promoting nuclear translocation of nuclear factor (erythroid-derived 2)-like 2; (Nrf2) and nuclear factor-κB (NF-κB). In this regard, quantitative profiles revealed different amounts of polyphenols, in particular quercetin levels were higher in plants under mineral fertilised treatment. Those extract showed an enhanced anti-inflammatory and antioxidant activity. Our data showed the anti-inflammatory and antioxidant potential of Maravilla de Verano polyphenolic extracts. The effect of farming methods on polyphenolic levels was highlighted. The higher reduction of inflammatory mediators release in extr...Continue Reading

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Citations

Apr 12, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carmela SaturninoMaria Stefania Sinicropi
Apr 20, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giacomo PepePietro Campiglia
Dec 23, 2021·Comprehensive Reviews in Food Science and Food Safety·Xiao YangFrancisco A Tomás-Barberán
Feb 6, 2020·Current Drug Discovery Technologies·Fatemeh Sadat HasheminasabMohammad Setayesh

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