Anti-inflammatory and antioxidant effect of cerium dioxide nanoparticles immobilized on the surface of silica nanoparticles in rat experimental pneumonia

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Z SerebrovskaV Dosenko

Abstract

A massage with the potent counter-inflammatory material, cerium dioxide nanoparticles, is promising and the antioxidant properties of CeO2 are considered the main, if not the only, mechanism of this action. Nevertheless, the elimination of ceria nano-particles from the organism is very slow and there is a strong concern for toxic effect of ceria due to its accumulation. To overcome this problem, we engineered a combined material in which cerium nanoparticles were immobilized on the surface of silica nanoparticles (CeO2 NP), which is shown to be easily removed from an organism and could be used as carriers for nano-ceria. In our study particle size was 220±5nm, Zeta-potential -4.5mV (in water), surface charge density -17.22μC/cm2 (at pH 7). Thirty-six male Wistar rats, 5 months old and 250-290g were divided into four groups: 1) control; 2) CeO2 NP treatment; 3) experimental pneumonia (i/p LPS injection, 1mg/kg); and 4) experimental pneumonia treated with CeO2 NP (4 times during the study in dosage of 0.6mg/kg with an orogastric catheter). Gas exchange and pulmonary ventilation were measured four times: 0, 1, 3 and 24h after LPS injection in both untreated and CeO2 NP-treated animals. The mRNA of TNF-α, Il-6, and CxCL2 were deter...Continue Reading

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Citations

Feb 8, 2020·Advanced Healthcare Materials·Shasha WangLiming Nie
Jul 15, 2020·Materials·Motaharesadat Hosseini, Masoud Mozafari
Mar 19, 2019·Journal of Biomedical Materials Research. Part a·Serena Del TurcoVirgilio Mattoli
Dec 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Raffaela FuccelliPatrizia Rosignoli
Nov 21, 2019·Nanomaterials·Marina S DukhinovaVladimir V Vinogradov
Aug 8, 2020·Frontiers in Microbiology·Yuzheng HuangJun Cao
Nov 24, 2020·Future Medicinal Chemistry·Chengcheng XiaYan Gao
Nov 13, 2020·Nano Today·Zhongmin TangWei Tao
Mar 30, 2021·International Journal of Nanomedicine·Shuai BianChunsheng Xiao
Aug 24, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mohd Aslam SaifiChandraiah Godugu
Oct 30, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Wali MuhammadChangyou Gao

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