PMID: 11902802Mar 21, 2002Paper

Anti-inflammatory and antioxidant properties of Helichrysum italicum

The Journal of Pharmacy and Pharmacology
Araceli SalaJ L Ríos

Abstract

The anti-inflammatory and antioxidant activities of the aerial part of Helichrysum italicum extracts have been established in various in-vivo and in-vitro experimental models. The results obtained on the acute oedemas induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) and ethyl phenylpropiolate in the mouse ear, by serotonin and phospholipase A2 (PLA2) in the mouse paw, on chronic inflammation induced by repeated application of TPA in the mouse ear and on the delayed-type hypersensitivity induced by sheep red blood cells suggest that said anti-inflammatory activity is due to the effects of compounds expressed via a corticoid-like mechanism. In addition, the antioxidant activity of the extracts seems to be implicated in this anti-inflammatory activity, as the former inhibits enzymatic and non-enzymatic lipid peroxidation and has free-radical scavenger properties. We conclude that the anti-inflammatory activity of Helichrysum italicum can be explained by multiple effects, including inflammatory enzyme inhibition, free-radical scavenging activity and corticoid-like effects.

Associated Clinical Trials

Apr 30, 2021·Zala Jenko Praznikar, Zala Jenko Praznikar

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Citations

Feb 6, 2003·European Journal of Pharmacology·Araceli SalaJosé Luis Rosí
Feb 1, 2003·European Journal of Pharmacology·Araceli SalaJosé-Luis Ríos
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