Anti-Inflammatory and Immune Regulatory Actions of Naja naja atra Venom

Toxins
Shu-Zhi Wang, Zheng-Hong Qin

Abstract

Naja naja atra venom (NNAV) is composed of various proteins, peptides, and enzymes with different biological and pharmacological functions. A number of previous studies have reported that NNAV exerts potent analgesic effects on various animal models of pain. The clinical studies using whole venom or active components have confirmed that NNAV is an effective and safe medicine for treatment of chronic pain. Furthermore, recent studies have demonstrated that NNAV has anti-inflammatory and immune regulatory actions in vitro and in vivo. In this review article, we summarize recent studies of NNAV and its components on inflammation and immunity. The main new findings in NNAV research show that it may enhance innate and humoral immune responses while suppressing T lymphocytes-mediated cellular immunity, thus suggesting that NNAV and its active components may have therapeutic values in the treatment of inflammatory and autoimmune diseases.

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Citations

Dec 12, 2018·Biophysical Reports·Na ChenFeng Wang
Jan 9, 2021·Toxicon : Official Journal of the International Society on Toxinology·C Minutti-ZanellaI Vergara

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Methods Mentioned

BETA
electrophoresis
nuclear translocation
flow cytometry
xenograft
light
transmission electron microscopy
MDA
bronchoalveolar lavage

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