Anti-inflammatory, anti-oxidative stress and novel therapeutic targets for cholestatic liver injury

Bioscience Trends
Yafei ZhangYiming Li

Abstract

Cholestasis is a pathological process in which bile drainage is poor for a variety of reasons. Many studies have shown that cholestatic liver injury is a neutrophil-mediated inflammatory response, and oxidative stress induced by neutrophils is the main mechanism of liver cell death. The literature summarizes the bile acid signaling pathway, the neutrophil chemotaxis recruitment process during cholestasis, and the oxidative stress damage produced by neutrophil activation, summarizes the latest research progress. Sphingosine-1-phosphate receptor (S1PR) is a potential therapeutic target for cholestasis that reduces neutrophil aggregation without inhibiting systemic immune status. Early growth response factor 1 (Egr-1) may play a central role in the inflammation induced by cholestasis, and it is also a potential therapeutic target to inhibit the inflammation induced by cholestasis. Strengthening the antioxidant system of hepatocytes to cope with oxidative stress of neutrophils is a feasible treatment for cholestatic liver injury.

References

Jan 14, 2003·The Journal of Biological Chemistry·Yuji KawamataMasahiko Fujino
Oct 18, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jaspreet S GujralHartmut Jaeschke
May 12, 2005·Toxicology and Applied Pharmacology·Udayan M ApteShashi K Ramaiah
Apr 15, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pratima KodaliJacquelyn J Maher
Aug 8, 2006·Cell Biochemistry and Function·Mehmet YilmazHalil Duzova
Feb 27, 2008·The Journal of Pharmacology and Experimental Therapeutics·Ming SongCraig J McClain
May 13, 2008·Biochemical and Biophysical Research Communications·Verena KeitelDieter Häussinger
Jun 19, 2009·The Journal of Surgical Research·Sacid CobanMukaddes Esrefoglu
Sep 8, 2009·Biochemical and Biophysical Research Communications·Kosuke OkadaMasayuki Yamamoto
Nov 26, 2009·Toxicology and Applied Pharmacology·Katryn AllenBryan L Copple
Apr 20, 2010·Journal of Pediatric Gastroenterology and Nutrition·G GalbiatiA Dhawan
Apr 19, 2011·The Journal of Nutritional Biochemistry·Wen-Ying ChenChun-Jung Chen
Nov 22, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Youcai ZhangCurtis D Klaassen
Feb 1, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jae-Hwi JangPierre-Alain Clavien
May 21, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Noémie PéanThierry Tordjmann
Jul 3, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Peter FickertMichael Trauner
Aug 28, 2013·Journal of Hepatology·Jittima WeerachayaphornJames L Boyer
Dec 7, 2013·Cellular Signalling·Mohammed QaisiyaClaudio Tiribelli
Mar 13, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yuxia ZhangLi Wang
Apr 20, 2014·Toxicology Letters·Benjamin L WoolbrightHartmut Jaeschke
May 20, 2014·Expert Opinion on Drug Metabolism & Toxicology·Mitchell R McGill, Hartmut Jaeschke
Jun 14, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mitchell R McGillUNKNOWN Acute Liver Failure Study Group
Aug 12, 2014·The Journal of Nutritional Biochemistry·Shih-Yi LinChun-Jung Chen
Jul 5, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Chien-Yun HsiangTin-Yun Ho
Oct 20, 2015·Expert Opinion on Therapeutic Targets·Benjamin L Woolbright, Hartmut Jaeschke
Oct 28, 2015·Genetics and Molecular Research : GMR·L Y KongZ Xi
Nov 19, 2015·Acta Pharmaceutica Sinica. B·Hannah JonesHeather Francis
Apr 7, 2016·Annual Review of Biochemistry·Christine C WinterbournMark B Hampton
Jan 1, 2013·ISRN Hepatology·Jian PengHeping Yang
Jan 28, 2017·British Journal of Pharmacology·Hang ZengHuichang Bi
Apr 4, 2017·Clinics in Liver Disease·Nathalie A Pena PolancoEric F Martin
Apr 19, 2017·Journal of Ethnopharmacology·Ya-Yu WangChun-Jung Chen
Jun 14, 2017·Molecular Aspects of Medicine·Man LiJames L Boyer

❮ Previous
Next ❯

Citations

Sep 29, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mengzhi ZouXinzhi Wang
Aug 8, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Kaihui ZhangChaozhan Lin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
Yan DingHan-ming Peng
Yao xue xue bao = Acta pharmaceutica Sinica
Xin-pin Zhuang, Qing Zhu
Seminars in Liver Disease
Bryan L CoppleCurtis D Klaassen
© 2022 Meta ULC. All rights reserved