Anti-inflammatory, antinociceptive and antipyretic properties of the aqueous extract of Clematis brachiata leaf in male rats

Pharmaceutical Biology
Mohammad MostafaA J Afolayan

Abstract

Clematis brachiata Thunb. (Ranunculaceae) is used as a folk remedy for the treatment of pain, fever and inflammatory ailments. Aqueous extract of Clematis brachiata leaf was screened for its phytochemical constituents. The anti-inflammatory investigations were carried out using carrageenan and histamine-induced edema models; acetic acid writhing, formalin-induced pain and tail immersion models were used to evaluate antinociceptive activity while a Brewer's yeast-induced hyperthermia model was employed for the antipyretic experiment. Phytochemical screening of the extract revealed the presence of tannins, saponins, flavonoids and cardiac glycosides. The extract at 100, 200 and 400 mg/kg body weight significantly (P<0.05) reduced the edema paw volumes induced by carrageenan and histamine with the 400 mg/kg body weight extract being the most potent. On the antinociceptive front, while the extract reduced the writhing caused by acetic acid and the number of licks induced by formalin in a dose dependent manner, the increase in the reaction time by the extract in the tail immersion model was not dose-dependent. Again, there was significant (P<0.05) lowering of the Brewer's yeast-provoked elevated body temperature. The results suggest...Continue Reading

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Citations

Jan 23, 2013·Pharmaceutical Biology·Christian AgyareKwesi Boadu Mensah
May 11, 2015·Journal of Ethnopharmacology·Lerato Seleteng KoseSandy Van Vuuren
Jun 26, 2012·Journal of Ethnopharmacology·Rakesh ChawlaAnupam Sharma
Jun 22, 2018·Chinese Journal of Integrative Medicine·Fu-Rong ZhuXun-Yu Xu
Jan 8, 2021·Journal of Ethnopharmacology·Fatma A MoharramDoaa G El-Hosari
Apr 29, 2021·International Urology and Nephrology·Ochbayasakh DashdondovXiaohui Zhou

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