Anti-inflammatory, antioxidant, anti-tyrosinase and phenolic contents of four Podocarpus species used in traditional medicine in South Africa

Journal of Ethnopharmacology
H S AbdillahiJohannes Van Staden

Abstract

Species of Podocarpus are used traditionally in their native areas for the treatment of fevers, asthma, coughs, cholera, chest complaints, arthritis, rheumatism, venereal diseases and distemper in dogs. To investigate the antioxidant, anti-inflammatory and anti-tyrosinase activities of four Podocarpus species, Podocarpus elongatus, Podocarpus falcatus, Podocarpus henkelii and Podocarpus latifolius, used in traditional medicine in South Africa. Phytochemical analysis to determine the phenolic contents was also carried out. DPPH, FRAP and β-carotene-linoleic acid assays were used to determine the antioxidant/radical scavenging activities of these species. Anti-inflammatory activity of these species was assayed against two cyclooxygenase enzymes (COX-1 and COX-2). Tyrosinase inhibition activity was analysed using the modified dopachrome method with l-DOPA as the substrate. Phenolics were quantitatively determined using spectrophotometric methods. Stems of Podocarpus latifolius exhibited the lowest EC(50) (0.84 μg/ml) inhibition against DPPH. The percentage antioxidant activity based on the bleaching rate of β-carotene ranged from 96% to 99%. High ferric reducing power was observed in all the extracts. For COX-1, the lowest EC(50) ...Continue Reading

References

Jun 1, 1997·Planta medica·H HaraguchiI Kubo
Jul 27, 1999·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·J T Lim
Mar 8, 2003·Pigment Cell Research·Stefania BrigantiMauro Picardo
May 2, 2003·Journal of Agricultural and Food Chemistry·Sung-Yum SeoNiti Sharma
May 10, 2003·Journal of Ethnopharmacology·Atta-ur RahmanM Iqbal Choudhary
May 25, 2004·The American Journal of Chinese Medicine·Jae Kyung NoHae Young Chung
Jul 28, 2004·Nitric Oxide : Biology and Chemistry·M-M Cals-Grierson, A D Ormerod
Jan 6, 2006·Biological & Pharmaceutical Bulletin·Jae Kyung NoHae Young Chung
Jul 18, 2006·Combinatorial Chemistry & High Throughput Screening·Athina A Geronikaki, Antonios M Gavalas
Feb 24, 2007·Journal of Ethnopharmacology·P J HoughtonG Steventon
Jun 2, 2007·Biological & Pharmaceutical Bulletin·You-Jung Kim
Oct 2, 2007·Phytochemistry·Oldrich Lapcík
Apr 2, 2008·Chemical & Pharmaceutical Bulletin·Yu-Jen KuoHsiu-O Ho
May 17, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·You Jung KimTakako Yokozawa

❮ Previous
Next ❯

Citations

Nov 11, 2011·International Journal of Molecular Sciences·Yang YaoGuixing Ren
Dec 23, 2011·Phytochemistry·Laura FaiellaAlessandra Braca
Feb 5, 2013·Pharmaceutical Biology·Xiao-Yan HeChun-Jie Wu
Dec 14, 2011·Journal of Ethnopharmacology·Halima S AbdillahiJohannes Van Staden
Aug 26, 2016·Natural Product Research·Juan LiuYegao Chen
Sep 15, 2016·Archives of Dermatological Research·Tatiana do Nascimento PedrosaEmerson Silva Lima
Sep 30, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuan-Dong ZhengSheng Yao
Nov 12, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abdulrahman M ElbagoryAhmed A Hussein
Feb 1, 2017·Journal of Asian Natural Products Research·Juan LiuYe-Gao Chen
Jul 23, 2014·Journal of the Science of Food and Agriculture·Muhammad Abubakar AdoKhozirah Shaari
Nov 7, 2019·Biochemistry Research International·Tabassum MullaJyoti Jadhav
Jan 1, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Mary GulumianVanessa Steenkamp
Nov 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Felipe Jiménez-AspeeGuillermo Schmeda-Hirschmann
May 13, 2018·Journal of Natural Medicines·Zhe-Ling FengLi-Gen Lin
Feb 9, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Samaneh ZolghadriAli Akbar Saboury
Jul 3, 2021·Journal of Ethnopharmacology·Myong Hak RiXuejun Jin
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·ChoEen KimMina Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

© 2021 Meta ULC. All rights reserved