Anti-inflammatory character of Phelligridin D modulates periodontal regeneration in lipopolysaccharide-induced human periodontal ligament cells

Journal of Periodontal Research
J-E KimH-K Yi

Abstract

Phelligridin D is a hispidin analogue from the mushroom Phellinus baumii that is widely used as a food source in East Asia. This study tested phelligridin D for the anti-inflammatory effect and mechanism in lipopolysaccharide (LPS)-induced human periodontal ligament cells (HPDLCs). The objective of this study was to clarify whether the anti-inflammatory function of phelligridin D affects periodontal regeneration for supporting the HPDLCs of teeth. Primary HPDLCs were isolated from healthy teeth and then cultured. The anti-inflammatory function, mechanism and differentiation molecules were verified with reactive oxygen species generation and western blot analysis in LPS-induced HPDLCs. HPDLCs showed increased inflammatory molecules (intracellular adhesion molecule-1 and vascular cell adhesion molecule-1) and decreased osteogenic proteins (bone morphogenetic protein-7, Osterix and runt-related transcription factor 2) by LPS treatment. Phelligridin D decreased inflammatory molecules and increased osteogenic molecules via downregulation of the extracellular signal-regulated kinase and c-jun N-terminal kinases pathway among the mitogen-activated protein kinase, followed by blocking of nuclear factor kappa-B translocation from cytoso...Continue Reading

References

Feb 1, 1995·Journal of Endodontics·R NissanH Trowbridge
Dec 5, 2003·Trends in Pharmacological Sciences·Holger UlbrichLennart Lindbom
Jul 21, 2005·Mediators of Inflammation·Cristina LullHuub F J Savelkoul
Oct 26, 2005·Journal of Dental Research·J ChangC-Y Wang
Jul 11, 2006·Journal of Periodontal Research·K NagatomoI Ishikawa
Oct 17, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yoshihiko SawaShigemitsu Yoshida
Mar 25, 2008·Journal of Endodontics·Jung-Chang LeeHo-Keun Yi
Jan 30, 2010·Journal of Dental Research·T M BoteroJ E Nör
Aug 17, 2010·Bioorganic & Medicinal Chemistry Letters·In-Kyoung LeeBong-Sik Yun
Jun 17, 2015·Bioorganic & Medicinal Chemistry Letters·Byung Soon HwangBong-Sik Yun
Jul 9, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Li WangWan-Chen Ning
Sep 2, 2016·BMC Complementary and Alternative Medicine·In-Ryoung KimSang-Hun Shin
Dec 13, 2016·The Biochemical Journal·Philip NewsholmePaulo Ivo Homem de Bittencourt
Jan 29, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Massimiliano GasparriniMaurizio Battino
Mar 17, 2017·International Scholarly Research Notices·Rajesh Gyawali, Bhagabat Bhattarai

❮ Previous
Next ❯

Citations

Oct 31, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Yue YangNing Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.