Anti-inflammatory constituents of Mortonia greggii Gray

Zeitschrift Für Naturforschung. C, a Journal of Biosciences
Amira Arciniegas M Teresa Ramirez ApanAlfonso Romo de Vivar

Abstract

A new phytochemical study of Mortonia greggii (Celastraceae) afforded four friedelan derivatives (1-4), three lupanes (5-7), retusine (8), two esterified polyhydroxyagarofurans (9-10), mortonin C (11) and photomortonin C (12). The anti-inflammatory activity on carrageenan and 12-O-tetradecanoylphorbol-13-acetate induced models of inflammation, as well as the ability to inhibit the nitric oxide (NO) produced by lipopolysaccharide-stimulated mouse peritoneal macrophages were evaluated for the main metabolites. Our results showed that the friedelan dehydrocanophyllic acid methyl ester (1) exhibits an anti-inflammatory effect which could be related to an inhibition of prostaglandin and NO production. The activity of lupeol (5), 29-hydroxylupeol (6) and 29-hydroxylupenone (7) might be involved with the prostanoid synthesis. The presence of the hydroxy groups in 6 appears to be important for activity. The edema inhibition capacity of retusine (8) could be related to a reduction of the prostaglandin production. The agarofuran derivative 10 is an NO inhibitor whose activity is probably not involved in the synthesis of prostaglandins.

Citations

May 31, 2012·Archives of Pharmacal Research·Seong Eun JinJae Sue Choi
Sep 28, 2007·Natural Product Reports·Jin-Ming GaoYasuo Konishi
Jun 23, 2018·Journal of Complementary & Integrative Medicine·Imran MahmudMd Khirul Islam
Jun 28, 2017·Chemical Research in Toxicology·Manuel A Ruiz-RodríguezRubén F González-Laredo
Dec 2, 2010·Life Sciences·Hifzur Rahman Siddique, Mohammad Saleem

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