Anti-inflammatory cyclopentene derivatives from the inner bark of Tabebuia avellanedae

Fitoterapia
Li ZhangTomihisa Ohta

Abstract

Six new cyclopentenyl esters, avellaneine A-F (1-4, 7, 8), two new cyclopentyl esters, avellaneine G, H (9, 10), along with two known cyclopentenyl esters were obtained from water extract of the inner bark of Tabebuia avellanedae Lorentz ex Griseb. The chemical structures of the new compounds were elucidated by spectroscopic techniques. The anti-inflammatory effects of these compounds were determined on LPS-stimulated RAW 264.7 cell line. Some of the tested compounds (2, 3, 4, 6, 7) reduced the NO production in a dose-dependent manner, while 6 and 7 decreased PGE2 production in a dose-dependent manner, without altering cell viability. Data presented in this research indicated that Tabebuia avellanedae's ethnopharmacological action of treating inflammatory diseases was based on the constituents which exert a significant anti-inflammatory effect on inflammatory responses.

References

Mar 22, 2000·Biochemical Systematics and Ecology· Lino von Poser G Rosendal Jensen S
May 23, 2000·Phytochemistry·J KoyamaK Hirai
Mar 21, 2001·Cellular Signalling·M Guha, N Mackman
Jul 20, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A RiffelA Brandelli
Dec 28, 2002·Journal of Agricultural and Food Chemistry·Byeoung-Soo ParkGary R Takeoka
Jun 3, 2005·Chemical & Pharmaceutical Bulletin·Suresh AwaleShigetoshi Kadota
Aug 17, 2005·Current Drug Targets. Inflammation and Allergy·Riku KorhonenEeva Moilanen
Dec 26, 2007·Transplant Immunology·Torsten BöhlerJochen Klupp
Nov 11, 2008·Journal of Ethnopharmacology·J Rubén Gómez CastellanosMichael Heinrich
Nov 22, 2008·Archives of Pharmacal Research·Cheol-Ho PanJae Kwon Lee
Aug 14, 2009·Bioorganic & Medicinal Chemistry·Mitsuaki YamashitaAkira Iida
Apr 25, 2012·Mediators of Inflammation·Andreas HaldKristoffer L Egerod
Sep 8, 2012·Fitoterapia·Maorong SuoTomihisa Ohta
Apr 16, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jung-Hye ShinDawon Kang

❮ Previous
Next ❯

Citations

May 8, 2018·Mediators of Inflammation·Jae Gwang ParkJae Youl Cho
Apr 29, 2020·Antioxidants·Georgia-Eirini DeligiannidouTheodoros Constantinides
Sep 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jianmei ZhangJae Youl Cho

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.