Anti-inflammatory drug-eluting implant model system to prevent wear particle-induced periprosthetic osteolysis

International Journal of Nanomedicine
Melissa C RiveraPolina Prokopovich

Abstract

Aseptic loosening, as a consequence of an extended inflammatory reaction induced by wear particles, has been classified as one of the most common complications of total joint replacement (TJR). Despite its high incidence, no therapeutical approach has yet been found to prevent aseptic loosening, leaving revision as only effective treatment. The local delivery of anti-inflammatory drugs to modulate wear-induced inflammation has been regarded as a potential therapeutical approach to prevent aseptic-loosening. In this context, we developed and characterized anti-inflammatory drug-eluting TiO2 surfaces, using nanoparticles as a model for larger surfaces. The eluting surfaces were obtained by conjugating dexamethasone to carboxyl-functionalized TiO2 particles, obtained by using either silane agents with amino or mercapto moieties. Zeta potential measurements, thermogravimetric analysis (TGA) and drug release results suggest that dexamethasone was successfully loaded onto the TiO2 particles. Release was pH dependent and greater amounts of drug were observed from amino route functionalized surfaces. The model-system was then tested for its cytotoxic and anti-inflammatory properties in LPS-stimulated macrophages. Dexamethasone released...Continue Reading

Citations

Sep 13, 2020·International Journal of Implant Dentistry·Fadi N BarrakJulian R Jones
Apr 2, 2021·Scientific Reports·Stefano PerniPolina Prokopovich
Sep 30, 2021·PloS One·Yazan Al ThaherPolina Prokopovich
Dec 29, 2021·Chemical Reviews·Kyoung Won ChoDae-Hyeong Kim

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Methods Mentioned

BETA
dynamic light scattering
ELISA
transmission electron microscopy

Software Mentioned

ImageJ

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