PMID: 9188924Apr 1, 1997Paper

Anti-inflammatory drugs do not alleviate bronchial hyperreactivity in Sjögren's syndrome

Allergy
G Stålenheim, B Gudbjörnsson

Abstract

Bronchial hyperreactivity (BHR) is found in Sjögren's syndrome, as in a number of other conditions such as asthma. BHR associated with asthma can be effectively treated with corticosteroids or sodium cromoglycate. We treated 19 Sjögren's syndrome patients with BHR with inhaled budesonide and inhaled cromoglycate for 6 weeks each. None of the treatment had any significant effect on symptoms of hyperreactivity or lung function. There was no effect on BHR measured as methacholine reactivity. Primary Sjögren's syndrome is a disease with inflammation not only in the salivary and lacrimal glands but also in the pulmonary alveoli and the bronchi. The main inflammatory cell is the lymphocyte, whereas, in the bronchi in asthma, the eosinophil granulocyte is the characteristic inflammatory cell. The cause of the discrepancy with regard to treatability of BHR in asthma and in Sjögren's syndrome is not known. Possibly not all BHR is caused by inflammation. There is not a perfect correlation between inflammation and hyperreactivity even in asthma. Even in the bronchial inflammation and the asthma symptoms are easy to treat with anti-inflammatory medicines, a considerable component of BHR usually still remains, as measured with methacholine ...Continue Reading

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Citations

Jun 2, 2016·European Respiratory Review : an Official Journal of the European Respiratory Society·Thomas FlamentSylvain Marchand-Adam
Nov 18, 2016·BMC Pulmonary Medicine·Te-Chun ShenDa-Tian Bau
Nov 17, 2016·Upsala Journal of Medical Sciences·Dora LudviksdottirBjörn Gudbjörnsson
Jan 26, 1999·Clinics in Chest Medicine·H C CainR A Matthay
Jan 5, 2011·La Presse médicale·Pierre-Yves HatronBenoît Wallaert

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