Abstract
Fluticasone furoate/Vilanterol trifenatate (FF/VI) is an inhaled corticosteroid/long-acting beta-agonist combination with a prolonged bronchodilator duration of action. We characterised the time-course of onset and offset of airway anti-inflammatory action of FF/VI, as assessed by fraction of exhaled nitric oxide (FeNO), and compared this to the bronchodilator duration of action. A single-centre, randomised, double-blind, placebo-controlled, two-period, crossover study was undertaken in 28 steroid-naïve adults with asthma. Participants with an FEV1 ≥ 60% predicted, reversible airway disease, and FeNO > 40 ppb received FF/VI 100/25 mcg or placebo once daily for 14 days. FeNO and peak expiratory flow were measured twice-daily during treatment and during a 21-day washout period. FEV1 was measured for five days from treatment cessation. The primary outcome measure was FeNO change from baseline ratio for 21 days following treatment cessation. In the 27 subjects who completed the study, median (range) baseline FeNO was 87 ppb (42-212). FF/VI 100/25 mcg reduced FeNO by day 3, ratio FF/VI versus placebo 0.72 (95% confidence interval 0.61-0.86) with the maximum reduction occurring at day 14, 0.32 (0.27-0.37). Following cessation of trea...Continue Reading
References
May 28, 1994·Annals of the New York Academy of Sciences·M LavioletteL P Boulet
Feb 1, 1996·The European Respiratory Journal·S A KharitonovP J Barnes
Jul 1, 1997·The European Respiratory Journal·D H YatesP J Barnes
Apr 22, 1999·Thorax·E L van RensenP J Sterk
May 18, 1999·Thorax·A JatakanonP J Barnes
Sep 18, 1999·The European Respiratory Journal·N C SantanelloB L Barber
Oct 18, 2000·Chest·I AzizB J Lipworth
May 12, 2001·Chest·P E SilkoffN Zamel
Sep 27, 2002·Thorax·S A KharitonovP J Barnes
Oct 3, 2002·The European Respiratory Journal·S L JonesD R Taylor
Sep 2, 2004·Respiratory Medicine·S M DennisS J Qureshi
Jun 19, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mark SalterDavid W Gray
Apr 12, 2008·Chest·Edward M ErinTrevor T Hansel
Sep 8, 2010·Lancet·Richard BeasleyMeme Wijesinghe
Sep 3, 2011·American Journal of Respiratory and Critical Care Medicine·Raed A DweikUNKNOWN American Thoracic Society Committee on Interpretation of Exhaled Nitric Oxide Levels (FENO) for Clinical Applications
Sep 17, 2011·European Journal of Pharmacology·Christos RossiosKazuhiro Ito
Dec 23, 2011·BMC Pulmonary Medicine·Brian J O'ConnorBrian Leaker
Mar 14, 2012·The Journal of Allergy and Clinical Immunology·Robert S TepperAlkis Togias
Aug 4, 2012·The Journal of Allergy and Clinical Immunology·Guiquan JiaUNKNOWN Bronchoscopic Exploratory Research Study of Biomarkers in Corticosteroid-refractory Asthma (BOBCAT) Study Group
Nov 8, 2012·The Journal of Pharmacology and Experimental Therapeutics·Robert J SlackRichard G Knowles
Nov 28, 2012·Clinical Pharmacokinetics·Ann AllenVicki M Rousell
Mar 16, 2013·Respiratory Medicine·Hendrik NolteFrederick Hargreave
Apr 25, 2014·Allergology International : Official Journal of the Japanese Society of Allergology·Hisako Matsumoto
Nov 26, 2014·Thorax·A H WagenerP J Sterk
Jan 15, 2016·The Lancet. Respiratory Medicine·Brian LipworthPhilip Short
Feb 27, 2016·The European Respiratory Journal·James FingletonUNKNOWN NZRHS Study Group
Oct 4, 2016·Respiratory Medicine·Irene BraithwaiteUNKNOWN FF/VI Study Team
Dec 23, 2016·Drug Design, Development and Therapy·Timothy E AlbertsonMark E Sutter
Aug 10, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Helen K ReddelSusan M Sawyer
Feb 2, 2018·The European Respiratory Journal
Citations
Oct 20, 2018·American Journal of Respiratory and Critical Care Medicine·Liam G HeaneyUNKNOWN Medical Research Council UK Refractory Asthma Stratification Programme (RASP-UK)
Dec 19, 2019·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Ross John LangleyDonald Urquhart
Jul 9, 2020·British Journal of Clinical Pharmacology·Holly TibbleHelen R Stagg
Nov 25, 2020·British Journal of Clinical Pharmacology·Brian LipworthChris Rui Wen Kuo
Oct 13, 2020·Journal of Breath Research·Tuomas KarvonenLauri Lehtimäki
Dec 8, 2021·Advances in Therapy·Peter Daley-YatesDave Singh