Anti-inflammatory effect of active nanofibrous polymeric membrane bearing nanocontainers of atorvastatin complexes

Nanomedicine
Pascale SchwintéNadia Benkirane-Jessel

Abstract

We developed polymeric membranes for local administration of nonsoluble anti-inflammatory statin, as potential wound patch in rheumatic joint or periodontal lesions. Electrospun polycaprolactone membranes were fitted with polysaccharide-atorvastatin nanoreservoirs by using complexes with poly-aminocyclodextrin. Characterization methods are UV-Visible and X-ray photoelectron spectroscopy, molecular dynamics, scanning and transmission electron microscopy. In vitro, membranes were seeded with macrophages, and inflammatory cytokine expression were monitored. Stable inclusion complexes were formed in solution (1:1 stability constant 368 M-1, -117.40 kJ mol-1), with supramolecular globular organization (100 nm, substructure 30 nm). Nanoreservoir technology leads to homogeneous distribution of atorvastatin calcium trihydrate complexes in the membrane. Quantity embedded was estimated (70-90 μg in 30 μm × 6 mm membrane). Anti-inflammatory effect by cell contact-dependent release reached 60% inhibition for TNF-α and 80% for IL-6. The novelty resides in the double protection offered by the cyclodextrins as drug molecular chaperones, with further embedding into biodegradable nanoreservoirs. The strategy is versatile and can target other di...Continue Reading

References

Oct 1, 1996·Journal of Pharmaceutical Sciences·T Loftsson, M E Brewster
Oct 16, 2002·Journal of Pharmaceutical Sciences·Thorsteinn LoftssonJóhanna F Sigurjónsdóttir
Oct 24, 2002·Journal of Computational Chemistry·Araz JakalianChristopher I Bayly
Dec 11, 2002·Kidney International·Luis Miguel Blanco-ColioJesús Egido
Oct 2, 2003·International Journal of Clinical Pharmacology and Therapeutics·A HilgendorffH Hölschermann
Oct 28, 2003·Journal of Dental Research·E AlsbergD J Mooney
Apr 30, 2004·Journal of Computational Chemistry·Junmei WangDavid A Case
Mar 4, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Ludovic RichertCatherine Picart
Jul 16, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sarah Gould, Robert C Scott
Sep 27, 2005·Trends in Cardiovascular Medicine·Claire ArnaudFrançois Mach
Oct 4, 2005·Journal of Computational Chemistry·David A CaseRobert J Woods
Feb 7, 2006·Journal of Molecular Graphics & Modelling·Junmei WangDavid A Case
May 26, 2006·Journal of Dental Research·K SakodaY Izumi
Jan 11, 2007·The Journal of Chemical Physics·Giovanni BussiMichele Parrinello
Nov 4, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·P J SalústioH M Cabral Marques
Mar 23, 2010·Cell·Charles A Dinarello
Apr 17, 2010·Mediators of Inflammation·X WitteboleP F Laterre
Jul 8, 2010·Australian Dental Journal·R Hirsch
Jan 21, 2011·Journal of Dental Research·M V Thomas, D A Puleo
Nov 5, 2011·International Wound Journal·Shadi FarsaeiEffat Sadat Farboud
Nov 5, 2011·Journal of Colloid and Interface Science·Wean Sin Cheow, Kunn Hadinoto
Dec 20, 2011·ACS Nano·Carlos Mendoza-PalomaresNadia Benkirane-Jessel
Mar 1, 2012·The Journal of Physical Chemistry. B·Wei David WangCecil Dybowski
Mar 24, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Wean Sin Cheow, Kunn Hadinoto
May 19, 2012·International Immunopharmacology·Eduardo Monguilhott DalmarcoTânia Silvia Fröde
Jul 25, 2012·BMC Research Notes·Alan W Sousa da Silva, Wim F Vranken
Nov 21, 2013·Journal of Medicinal Chemistry·Yang YangYu Liu
Mar 25, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Rosella CiurleoSilvia Marino
May 23, 2014·Journal of Chemical Information and Modeling·Rashmi KumariAndrew Lynn
Jan 1, 2008·Journal of Chemical Theory and Computation·Berk Hess
Mar 1, 2008·Journal of Chemical Theory and Computation·Berk HessErik Lindahl
Jan 14, 2016·Scientific Reports·Yang YangYu Liu

❮ Previous
Next ❯

Citations

Feb 28, 2019·Journal of Applied Biomaterials & Functional Materials·Patrícia VarelaGianluca Ciardelli
Apr 3, 2019·Mediators of Inflammation·Catherine PetitOlivier Huck
Jun 22, 2019·Colloids and Surfaces. B, Biointerfaces·Marie DubusHalima Kerdjoudj
Jul 29, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Parisa HeydariShaghayegh Haghjooy Javanmard

❮ Previous
Next ❯

Methods Mentioned

BETA
Quartz Crystal Microbalance
transmission
scanning electron microscopy
x-ray photoelectron spectroscopy
ELISA
Fluorescence
solubility studies
nuclear magnetic resonance
transmission electron microscopy

Software Mentioned

Lab Power Junior
AMBER Building Energy
acpype python script
CasaXPS
GROMACS
AmberTools
mmpbsa
GraphPad
APBS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved