Anti-inflammatory Effect of Alloferon on Ovalbumin-induced Asthma

Immune Network
Jane JeonWang Jae Lee

Abstract

Asthma is a well-known inflammatory lung disease; however, the specific underlying mechanism is largely unknown. We previously demonstrated that alloferon effectively downregulates pulmonary inflammation. In this study, we examined whether alloferon has a therapeutic effect on asthma. Alloferon remarkably decreased the number of eosinophils, macrophages, and neutrophils in the bronchoalveolar lavage fluid (BALF) from ovalbumin (OVA)-induced asthma mice. It was synergistically decreased with 2.5 mg/kg prednisolone (PDA). Inflammatory cell infiltration around the bronchioles and in the alveolus of OVA-induced asthma mice was effectively prevented by alloferon alone and combined treatment with alloferon and PDS. The production of IL-5 and IL-17 was decreased by alloferon alone and combined treatment with alloferon and PDS. There was no change the level of total immunoglobulin (Ig) following alloferon administration; however, total Ig was decreased by PDS. IgG2a levels were not changed by either alloferon alone or alloferon in combination with PDS. However, the levels of OVA-specific IgG1 and IgE were decreased by alloferon and PDS. In conclusion, our results suggest that a combination of alloferon and prednisolone is effective for...Continue Reading

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Citations

Jul 15, 2017·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Sulgi YooJae Youl Cho
Jan 19, 2018·Molecular Medicine Reports·Wei LeiJianan Huang
Sep 30, 2016·Journal of Applied Toxicology : JAT·Jun-Kyoung LeeSang-Hyun Kim

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Methods Mentioned

BETA
bronchoalveolar
ELISA

Software Mentioned

GraphPad
GraphPad InStat

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