Anti-inflammatory effect of cinnamaldehyde in Helicobacter pylori induced gastric inflammation.

Biological & Pharmaceutical Bulletin
Jibran Sualeh MuhammadToshiro Sugiyama

Abstract

Cinnamomum cassia is widely employed for gastrointestinal complaints such as dyspepsia, flatulence, diarrhea, and vomiting. Studies report cinnamaldehyde (CM) as a major active constituent of cinnamon. The aim of this study was to evaluate the anti-inflammatory mechanism of CM on Helicobacter (H.) pylori-infected gastric epithelial cells in order to validate cinnamon traditional use in gastrointestinal (GI)-related disorders. AGS/MKN-45 cells and H. pylori (193C) were employed for co-culture experiments. Anti-H. pylori cytotoxic and anti-adhesion activity of CM were determined. Enzyme linked immunosorbent assay, real time polymerase chain reaction analysis and immunoblotting were used to measure the effect on interleukin-8 (IL-8) secretion/expression. The effect on activation of nuclear factor kappa B (NF-κB) was determined by immunoblot analysis. The non-cytotoxic CM (≤125 µM) was also non-bactericidal at the given time, suggesting the effect in H. pylori/cell co-culture system was not due to alteration in H. pylori viability or the toxicity to the cells. Also, CM did not show any anti-adhesion effect against H. pylori/cell co-culture. However, pre-incubation of the cells with CM significantly inhibited the IL-8 secretion/expr...Continue Reading

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Citations

Jan 21, 2016·Microbial Cell Factories·Hyun Bae BangKi Jun Jeong
Sep 16, 2016·The American Journal of Chinese Medicine·Guan-Yu ChenYuan-Chuen Wang
Oct 19, 2016·Immunopharmacology and Immunotoxicology·Feng XuNan Zeng
Sep 25, 2017·Nutrition and Cancer·Syed Faisal ZaidiToshiro Sugiyama
Jan 27, 2018·Journal of Translational Medicine·Ajaikumar B KunnumakkaraBharat B Aggarwal
Jul 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Qing LiuHua-Bin Li
Nov 12, 2018·Fish & Shellfish Immunology·Simon Menanteau-LedoubleMansour El-Matbouli

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