Anti-inflammatory effect of fullerene C60 in a mice model of atopic dermatitis

Journal of Nanobiotechnology
Nadezda ShershakovaMusa Khaitov

Abstract

Water-soluble form of fullerene C60 is a promising tool for the control of ROS-dependent inflammation including allergic diseases. Anti-inflammatory effects of C60 (nC60) aqueous dispersion were evaluated in the mouse models of atopic dermatitis using subcutaneous (SC) and epicutaneous (EC) applications during 50 days period. A highly stable nC60 was prepared by exhaustive dialysis of water-organic C60 solution against water, where the size and ζ-potential of fullerene nanoparticles are about 100 nm and -30 mV, respectively. To induce skin inflammation, female BALB/c mice were EC sensitized with ovalbumin three times during one-weekly exposures. The nC60 solution was administrated in mice subcutaneously (SC) (0.1 mg/kg) and epicutaneously (EC) (1 mg/kg). Significant suppression of IgE and Th2 cytokines production and a concomitant rise in concentrations of Th1 cytokines were observed in nC60-treated groups. In addition, a significant increase in the levels of Foxp3(+) and filaggrin mRNA expression was observed at EC application. Histological examination of skin samples indicated that therapeutic effect was achieved by both EC and SC treatment, but it was more effective with EC. Pronounced reduction of the eosinophil and leukocy...Continue Reading

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Citations

Dec 17, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Brian C Palmer, Lisa A DeLouise
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Nov 27, 2019·Nano-micro Letters·Xinhong LiYafei Zhang

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Methods Mentioned

BETA
ELISA
PCR
biopsies

Software Mentioned

Statistica

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