Anti-inflammatory effect of resveratrol by inhibition of IL-8 production in LPS-induced THP-1 cells

The American Journal of Chinese Medicine
You-Chang OhDong-Yeul Kwon

Abstract

Resveratrol is a polyphenol compound and prominent anti-inflammatory agent found in plants, including the fruits of Morus alba. However, the therapeutic mechanisms of resveratrol remain largely unclear. To gain insight into the biological effects of resveratrol, we examined its influence on LPS-induced IL-8 production in the human monocytic cell line, THP-1. In inflammatory diseases, IL-8 plays a central role in the initiation and maintenance of inflammatory response. In the present study, IL-8 production was measured by ELISA and RT-PCR, while MAPK activation, IkappaBalpha degradation, nuclear factor (NF)-kappaB activation and cyclooxygenase (COX)-2 expression were determined by Western blot analysis. Resveratrol inhibited LPS-induced IL-8 production in a dose-dependent manner. Furthermore, resveratrol inhibited extracellular signal-regulated kinase (ERK) and p38 MAPK phosphorylation, IkappaBalpha degradation, NF-kappaB activation and cyclooxygenase (COX)-2 expression, which suggest that resveratrol inhibits IL-8 secretion by blocking MAPK phosphorylation and NF-kappaB activation. Taken together, these findings may help elucidate the mechanism by which resveratrol modulates THP-1 cell activation under inflammatory conditions.

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Citations

Oct 30, 2012·The Journal of Biological Chemistry·Hee Ra ParkJaewon Lee
Sep 11, 2010·Journal of Medicinal Food·You-Chang OhDong-Yeul Kwon
Aug 26, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Philip Chiu-Tsun TangShun-Wan Chan
Jul 6, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M A SiddiquiA B Pant
Jan 26, 2011·Annals of the New York Academy of Sciences·Qingyong MaHuanchen Sha
Sep 4, 2015·Chemico-biological Interactions·Martina GobecŽiga Jakopin
Sep 17, 2013·Biochimica Et Biophysica Acta·Guido A GualdoniGerhard J Zlabinger
Sep 8, 2012·Food Chemistry·Martha-Estrella García-PérezTatjana Stevanovic
Feb 29, 2020·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Minoo ShahidiMahmood Barati
Jan 1, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Lakhan Kma
Jun 15, 2017·BMC Complementary and Alternative Medicine·Joseph SchwagerDaniel Raederstorff
Mar 4, 2021·Nutrients·Manuela CassottaMaurizio Battino

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