Anti-Inflammatory Effect of Rosa rugosa Flower Extract in Lipopolysaccharide-Stimulated RAW264.7 Macrophages

Biomolecules & Therapeutics
Xirali TursunHaji AkberAisa

Abstract

Rosa rugosa Thunb, a deciduous shrub of the genus Rosa, has been widely used to treat stomach aches, diarrhoea, pain, and chronic inflammatorydisease in eastern Asia. In recent years, our research team has extensively studied the Rosa rugosa flowerextract, and specificallyundertook pharmacological experiments which have optimized the extraction process. Our methods have yielded a standard extract enriched in phenolic compounds, named PRE. Herein, we expand our efforts and evaluated the antiinflammatoryactivity of PRE on lipopolysaccharide (LPS)-induced inflammationin RAW 264.7 macrophages. PRE significantlyinhibited production of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor (TNF)-α, interleukin (IL)-6, and interleukin 1β (IL-1β), as well as expression of their synthesizing enzymes, inducible nitric oxide synthase (iNOS) and cyclooxygenase2 (COX-2). Furthermore, PRE inhibited activity of mitogen-activated protein kinases (MAPK) as well as nuclear factor-kappa B (NF-κB) signaling pathway. Our findingsare the firstto explain the anti-inflammatorymechanism by PRE in LPS-stimulated macrophages. Given these results, we propose that PRE has therapeutic potential in the prevention of inflammatory disorders.

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Citations

Apr 4, 2017·The American Journal of Chinese Medicine·Jae Sik YuJae Youl Cho
Jun 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cai Yi WangYoung Ho Kim
Aug 24, 2017·Pharmaceutical Biology·Gyubyung ParkJae Youl Cho
Jun 10, 2017·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Xuehui ZhangRong Qi
Jan 19, 2018·Molecular Medicine Reports·Yuxin BaoGuanghong Xie
Jun 4, 2020·Environmental Science and Pollution Research International·Shirin MoradkhaniAmir Nili-Ahmadabadi
Mar 25, 2021·Phytochemistry·Hongliang LiHaji Akber Aisa
Jul 5, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Dilaram NijatH A Aisa
Jun 28, 2019·Journal of Agricultural and Food Chemistry·Suk Woo ChangDae Sik Jang

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Methods Mentioned

BETA
protein assay
ELISA
electrophoresis

Software Mentioned

Chromeleon
ImageJ

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