Anti-inflammatory effect of Stereospermum suaveolens ethanol extract in rats

Pharmaceutical Biology
T BalasubramanianSundar Lal Meena

Abstract

The anti-inflammatory effect of the ethanol extract of Stereospermum suaveolens (Roxb.) DC (Bignoniaceae) bark given orally at the dose of 200 and 400 mg/kg body weight was studied in rats using the carrageenan-, dextran-, and histamine-induced hind paw edema, and cotton pellet-induced granuloma formation models. Indomethcin at the dose of 10 mg/kg body weight was used as a standard drug. The extract (400 mg/kg body weight per os) showed maximum inhibition of edema 64.6, 53.48, and 50.06% at the end of 3 h with carrageenan-, dextran-, and histamine-induced rat paw edema, respectively. The extract (400 mg/kg) exhibited significant reduction (34.77%) in granuloma weight in the cotton pellet-induced granuloma model. From these results it could be concluded that, the ethanol extract of Stereospermum suaveolens possesses maximum anti-inflammatory activity in a dose-dependent manner, in various experimental models.

References

Sep 1, 1957·Journal of the American Pharmaceutical Association·C A WINTER, C C PORTER
Dec 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·C A WINTERG W NUSS
May 4, 2004·Journal of Ethnopharmacology·Ampai PanthongVichai Reutrakul
Oct 10, 2006·Phytochemistry·Mohammad R HaqueMohammad A Rashid

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